That’s because it’s prone to introducing unexpected mutations that are hard to spot, and it can generate embryos with a mixture of edited and unedited cells.
The “staged rollout” of gene-modified babies could start with sickle-cell disease|Amy Nordrum|September 3, 2020|MIT Technology Review
Gene editing might be an option when 25 percent or fewer of a couple’s embryos would be free of the disease-causing mutation.
Strict new guidelines lay out a path to heritable human gene editing|Tina Hesman Saey|September 3, 2020|Science News
When geneticists need to understand what genes do, they can create laboratory mice with “knockout” mutations and see whether and how the animals cope with the loss.
By Losing Genes, Life Often Evolved More Complexity|Viviane Callier|September 1, 2020|Quanta Magazine
Dowling’s theory predicts that the faster the mitochondrial mutation rate is, the more often the members of that species will need to have sex.
Sex Is Driven by the Impetus to Change - Issue 88: Love & Sex|Jill Neimark|August 12, 2020|Nautilus
Without sex we’d have a situation where mitochondrial mutations accumulate much faster and the nucleus could not come up quickly enough with co-adapted mutations.
Sex Is Driven by the Impetus to Change - Issue 88: Love & Sex|Jill Neimark|August 12, 2020|Nautilus
Those with the disease have some cells that are genetically normal and some with the mutation.
The True Story of ‘The Elephant Man’|Russell Saunders|November 3, 2014|DAILY BEAST
For some illnesses, having a mutation in one specific gene usually—but not always—caused disease.
The Genetic Heroes That Could Cure the Sick|Carrie Arnold|July 1, 2014|DAILY BEAST
This was a mutation of a relationship that should, in theory, be unbreakably strong.
Their Cordial Meeting Proves the Common Bonds of Obama and Pope Francis|Joshua DuBois|March 27, 2014|DAILY BEAST
If a mutation makes a single cell deaf to the needs of its body, it can develop into a tumor.
‘Zoobiquity’: What Animals Can Teach Us About Our Health|Carl Zimmer|June 17, 2012|DAILY BEAST
The answer may be that the birther phenomenon is a mutation of a political virus called incoherence.
Will the Birthers Doom the GOP?|John Batchelor|July 28, 2009|DAILY BEAST
This theory of Mutation has been eagerly seized upon by many botanists.
The Meaning of Evolution|Samuel Christian Schmucker
Be that as it may, the neo-Darwinians are inclined to admit that the periods of mutation are determinate.
Creative Evolution|Henri Bergson
Dilution might make it not work—the mutation might not take place—but it couldnt make it half work.
Greener Than You Think|Ward Moore
But suppose that no mutation occurs more frequently than the others.
The Making of Species|Douglas Dewar
At present our knowledge of the causes of variation and mutation is practically nil.
The Making of Species|Douglas Dewar
British Dictionary definitions for mutation
mutation
/ (mjuːˈteɪʃən) /
noun
the act or process of mutating; change; alteration
a change or alteration
a change in the chromosomes or genes of a cell. When this change occurs in the gametes the structure and development of the resultant offspring may be affectedSee also inversion (def. 11)
another word for mutant (def. 1)
a physical characteristic of an individual resulting from this type of chromosomal change
phonetics
(in Germanic languages) another name for umlaut
(in Celtic languages) a phonetic change in certain initial consonants caused by a preceding word
An alteration or change, as in nature, form, or quality.
A sudden structural change within a gene or chromosome of an organism resulting in the creation of a new character or trait not found in the parental type.
The process by which such a sudden structural change occurs, either through an alteration in the nucleotide sequence of the DNA coding for a gene or through a change in the physical arrangement of a chromosome.
A change in the structure of the genes or chromosomes of an organism. Mutations occurring in the reproductive cells, such as an egg or sperm, can be passed from one generation to the next. Most mutations occur in junk DNA and have no discernible effects on the survivability of an organism. Of the remaining mutations, the majority have harmful effects, while a minority can increase an organism's ability to survive. A mutation that benefits a species may evolve by means of natural selection into a trait shared by some or all members of the species. See Note at sickle cell anemia.