aldose reductase

al·dose re·duc·tase

polyol dehydrogenase (NADP⁺); an oxidoreductase that reversibly converts aldoses to alditols (for example, glucose to sorbitol) with NADPH as hydride donor, an important step in the metabolism of sorbitol and in the formation of diabetes-associated cataracts.
See also: d-sorbitol-6-phosphate dehydrogenase.

aldose reductase

An NADPH-dependent oxidoreductase (EC 1.1.1.21) that catalyses the reduction of various aldehydes and carbonyls (e.g., glucose into sorbitol), which is the first step in the polyol pathway of glucose metabolism. Excess sorbitol in the eye, nerves and kidneys in diabetics leads to retinopathy, neuropathy and nephropathy.

aldose reductase

An enzyme normally present in the eye and elsewhere, which converts excess glucose–as occurs in DM—into sorbitol; excess sorbitol in the eye, nerves, and kidneys can lead to retinopathy, neuropathy, and nephropathy. See Aldose reductase inhibitors.

aldose reductase

An enzyme that makes up part of the metabolic pathway that converts glucose to fructose and sorbitol. Fructose and sorbitol may damage nerves, the retina, and the lens of the eye when they accumulate excessively, e.g., in poorly controlled diabetes mellitus.

单词	aldose reductase
释义	aldose reductase al·dose re·duc·tase polyol dehydrogenase (NADP⁺); an oxidoreductase that reversibly converts aldoses to alditols (for example, glucose to sorbitol) with NADPH as hydride donor, an important step in the metabolism of sorbitol and in the formation of diabetes-associated cataracts. See also: d-sorbitol-6-phosphate dehydrogenase. aldose reductase An NADPH-dependent oxidoreductase (EC 1.1.1.21) that catalyses the reduction of various aldehydes and carbonyls (e.g., glucose into sorbitol), which is the first step in the polyol pathway of glucose metabolism. Excess sorbitol in the eye, nerves and kidneys in diabetics leads to retinopathy, neuropathy and nephropathy. aldose reductase An enzyme normally present in the eye and elsewhere, which converts excess glucose–as occurs in DM—into sorbitol; excess sorbitol in the eye, nerves, and kidneys can lead to retinopathy, neuropathy, and nephropathy. See Aldose reductase inhibitors. aldose reductase An enzyme that makes up part of the metabolic pathway that converts glucose to fructose and sorbitol. Fructose and sorbitol may damage nerves, the retina, and the lens of the eye when they accumulate excessively, e.g., in poorly controlled diabetes mellitus. AcronymsSeeair route
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