hypereosinophilic syndrome


hypereosinophilic syndrome

 [hi″per-e″o-sin″o-fil´ik] any of several diseases characterized a massive increase in the number of eosinophils in the blood and bone marrow, with eosinophilic infiltration of other organs. Symptoms vary, depending on the organ involved, and may include pruritic skin ulcers or erythroderma, endomyocarditis, lymph node or spleen enlargement, and ophthalmologic or gastrointestinal complications. Eosinophilic leukemia is a potentially fatal member of the group.

hy·per·e·o·sin·o·phil·ic syn·drome

persistent peripheral eosinophilia with eosinophilic infiltration into bone marrow, heart, and other organ systems; accompanied by nocturnal sweating, coughing, anorexia and weight loss, itching and various skin lesions, and symptoms of Löffler endocarditis.

hypereosinophilic syndrome

(hī′pər-ē′ə-sĭn′ə-fĭl′ĭk)n. Any of various syndromes in which the concentration of eosinophils increases in peripheral blood with later infiltration into bone marrow, heart, and other organ systems.

hypereosinophilic syndrome

A heterogeneous group of conditions characterized by persistent peripheral eosinophilia with infiltration of eosinophils in BM, heart, and other organs, which may be a form of myeloproliferative disorder–possibly eosinophilic leukemia as 1. 25% have chromosomal abnormalities–eg, aneuploidy and ↓ vitamin B12 with persistent eosinophilia–> 1500 x 109/L for > 6 months;.2. Absence of 2º causes of eosinophilia, despite aggressive workup;.3. Sx due to organ involvement or dysfunction Clinical Age of onset, 20–50, generalized weakness, dyspnea, cough, malaise, myalgia, anorexia, angioedema, rash, low-grade fever, night sweats, weight loss, rhinitis, and Sx of Löffler's endocarditis; eosinophils cause dysfunction in heart, BM, liver, spleen, CNS, either focal–due to emboli–or diffuse, causing altered behavior and cognition, psychosis, ataxia, spasticity, peripheral symmetrical polyneuropathy, coma, GI tract–diarrhea, abdominal pain, malabsorption, lungs–interstitial inflammation with eosinophils, and skin–nonspecific rashes; once the heart is involved–eg, endocardial fibrosis, thrombosis and restrictive cardiomyopathy, death < 1 yr Management Possibly corticosteroids.

hy·per·e·o·sin·o·phil·ic syn·drome

(hī'pĕr-ē'ō-sin-ō-fil'ik sin'drōm) Persistent peripheral eosinophilia with later infiltration into bone marrow, heart, and other organ systems; accompanied by nocturnal sweating, coughing, anorexia and weight loss, itching, various skin lesions, and symptoms of Löffler endocarditis.

hy·per·e·o·sin·o·phil·ic syn·drome

(hī'pĕr-ē'ō-sin-ō-fil'ik sin'drōm) Persistent peripheral eosinophilia with eosinophilic infiltration into bone marrow, heart, and other organ systems; accompanied by nocturnal sweating, coughing, and anorexia and weight loss.