hyperimmunoglobulin E syndrome

hy·per·im·mu·no·glob·u·lin E syn·drome

an immunodeficiency disorder characterized by high levels of plasma IgE concentrations, a leukocyte chemotactic defect, and recurrent staphylococcal infections, and cold-abscess formatin in the skin, upper respiratory tract, and other sites. Synonym(s): Job syndrome

An immunodeficiency characterised by multiple recurring abscesses
Lab Defects in neutrophil and monocyte chemotaxis, increased IgE

hyperimmunoglobulin E syndrome

Hyper-IgE syndrome, Job syndrome Immunology An AR immunodeficiency characterized by chronic eczematoid lesions, recurring abscesses of skin, lungs, joints, recurring otitis media, sinusitis, life-threatening staphylococcal infections, chronic eczemoid lesions and recurring abscesses of lungs, skin, joints, eyes, ears by Staph aureus, H influenzae, S pneumoniae, group A streptococci, Candida spp Lab ↑ Eosinophils, IgE > 5000 IU/mL, ↓ antibody response to vaccines and MHC antigens, ↓ CD4:CD8–T cell helper:suppressor ratio, defects in PMN and monocyte chemotaxis, defects in PMN and monocyte chemotaxis, ↑ IgE Prognosis Prolonged survival is possible

hy·per·im·mu·no·glob·u·lin E syn·drome

(hī'pĕr-im'yū-nō-glob'yū-lin sin'drōm) An immunodeficiency disorder characterized by high levels of plasma IgE concentrations, a leukocyte chemotactic defect, and recurrent staphylococcal infections of the skin, upper respiratory tract, and other sites.

单词	hyperimmunoglobulin e syndrome
释义	hyperimmunoglobulin E syndrome hy·per·im·mu·no·glob·u·lin E syn·drome an immunodeficiency disorder characterized by high levels of plasma IgE concentrations, a leukocyte chemotactic defect, and recurrent staphylococcal infections, and cold-abscess formatin in the skin, upper respiratory tract, and other sites. Synonym(s): Job syndrome An immunodeficiency characterised by multiple recurring abscesses Lab Defects in neutrophil and monocyte chemotaxis, increased IgE hyperimmunoglobulin E syndrome Hyper-IgE syndrome, Job syndrome Immunology An AR immunodeficiency characterized by chronic eczematoid lesions, recurring abscesses of skin, lungs, joints, recurring otitis media, sinusitis, life-threatening staphylococcal infections, chronic eczemoid lesions and recurring abscesses of lungs, skin, joints, eyes, ears by Staph aureus, H influenzae, S pneumoniae, group A streptococci, Candida spp Lab ↑ Eosinophils, IgE > 5000 IU/mL, ↓ antibody response to vaccines and MHC antigens, ↓ CD4:CD8–T cell helper:suppressor ratio, defects in PMN and monocyte chemotaxis, defects in PMN and monocyte chemotaxis, ↑ IgE Prognosis Prolonged survival is possible hy·per·im·mu·no·glob·u·lin E syn·drome (hī'pĕr-im'yū-nō-glob'yū-lin sin'drōm) An immunodeficiency disorder characterized by high levels of plasma IgE concentrations, a leukocyte chemotactic defect, and recurrent staphylococcal infections of the skin, upper respiratory tract, and other sites.
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