hereditary nonpolyposis colon cancer

hereditary nonpolyposis colon cancer

Lynch I syndrome Oncology A relatively distinct AD form of cancer that may account for 5-10% of all colorectal CA Clinical Family Hx of colorectal CA at relatively young age, primarily of proximal colon, tendency toward multiple primary tumors; HNPCC may be ssociated with extracolonic tumors–eg, of endometrium Diagnosis Amsterdam criteria. See Amsterdam criteria, Colorectal cancerhMSH-2. Cf Familial adenomatous polyposis.