alpha-1 antitrypsin

A 54-kD glycoprotein that inhibits proteolytic enzymes (proteases), trypsin, chymotrypsin, elastases in lysosomes, plasmin, thrombin, collagenase and others; serum A1AT is a so-called acute-phase reactant.
Increased A1AT
Inflammation, liver injury, increased oestrogen, pregnancy, malignancy, corticosteroid therapy.

Decreased A1AT
Heterozygous A1AT deficiency, emphysema, prematurity, protein-losing disorders; by immunohistochemistry, A1AT stains atypical fibroxanthoma, granular cell tumour and papillary carcinoma of the thyroid.

Ref range
2–4 g/L

单词	alpha-1 antitrypsin
释义	alpha-1 antitrypsin alpha-1 antitrypsin A 54-kD glycoprotein that inhibits proteolytic enzymes (proteases), trypsin, chymotrypsin, elastases in lysosomes, plasmin, thrombin, collagenase and others; serum A1AT is a so-called acute-phase reactant. Increased A1AT Inflammation, liver injury, increased oestrogen, pregnancy, malignancy, corticosteroid therapy. Decreased A1AT Heterozygous A1AT deficiency, emphysema, prematurity, protein-losing disorders; by immunohistochemistry, A1AT stains atypical fibroxanthoma, granular cell tumour and papillary carcinoma of the thyroid. Ref range 2–4 g/L
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