granulovacuolar degeneration


gran·u·lo·vac·u·o·lar de·gen·er·a·tion

degeneration of hippocampal brain cells in old people, characterized by basophilic granules surrounded by a clear zone in hippocampal neurons; occurs more frequently in Alzheimer disease.

granulovacuolar degeneration

A pathological finding in the brain cells of some patients with Alzheimer's dementia in which the neuronal cytoplasm is partly replaced by cavities that contain particles resembling grit or sand.See also: degeneration