grape seed extract


grape seed extract

(grayp seed ex-trakt) grapeseedextract,

Vitis vinifera

(trade name),

Vitis coignetiae

(trade name),

Oligomeric Proanthocyanidins (OPCs)

(trade name)

Classification

Therapeutic: cardioprotective agents
Chronic venous insufficiency, edema, diabetic retinopathy, varicose veins, cancer prevention, atherosclerosis, cirrhosis, prevention of collagen breakdown, vision problems, constipation, antioxidant, wound healing.

Action

Grape flavonoids have a wide range of effects including antioxidant, vasodilatory, antiplatelet, decreased superoxide production, free-radical removal and inhibition of collagenase.

Therapeutic effects

Reduced risk of coronary disease.Decreased skin and vasculature breakdown.

Pharmacokinetics

Absorption: Unknown.Distribution: Unknown.Metabolism and Excretion: Unknown.Half-life: Unknown.

Time/action profile

ONSETPEAKDURATION
POUnknownUnknownUnknown

Contraindications/Precautions

Contraindicated in: Hypersensitivity or allergy to grape seed extract; Patients with bleeding disorders or receiving anticoagulant therapy.Use Cautiously in: Obstetric: Avoid use in pregnancy due to lack of safety data.

Adverse Reactions/Side Effects

Cardiovascular

  • hypertension

Central nervous system

  • dizziness
  • headache

Dermatologic

  • dry skin

Ear, Eye, Nose, Throat

  • sore throat
  • cough

Gastrointestinal

  • nausea
  • diarrhea

Hematologic

  • ↑ risk of bleeding

Interactions

May ↑ anticoagulant effects of warfarin.May ↓ plasma levels of CYP1A2 substrates.May inhibit the growth of lactobacillus acidophilus.May ↑ BP in hypertensive patients also takingvitamin c.Oral (Adults) 75–300 mg daily.

Availability

Tablets : Capsules:

Nursing implications

Nursing assessment

  • Monitor BP periodically during therapy.
  • Lab Test Considerations: Monitor serum cholesterol levels periodically during therapy.

Potential Nursing Diagnoses

Activity intolerance (Indications)

Implementation

  • Administer as directed. Doses may vary.

Patient/Family Teaching

  • Advise patient not to take grape seed extract with Vitamin C; may cause increase in BP.
  • Advise female patients to notify health care professional if pregnancy is planned or suspected.

Evaluation/Desired Outcomes

  • Decrease in cholesterol.
  • Decrease in BP.

grape seed extract

Abbreviation: GSE
An extract of antioxidant oils isolated from the seeds of grapes (Vitis vinifera) and promoted by alternative and complementary medical practitioners as a potential treatment for coronary artery disease, cancer, and other illnesses produced or worsened by oxidative stresses on body tissues. The extract has been used as a traditional European remedy for diseases of the eyes and skin seems to reduce postoperative swelling faster than placebo. Scientific evidence for its clinical effectiveness is sparse. See also: extract