释义 |
DictionarySeeVitis viniferaEncyclopediaSeeextractgrape seed extract
grape seed extract (grayp seed ex-trakt) grapeseedextract, Vitis vinifera (trade name), Vitis coignetiae (trade name), Oligomeric Proanthocyanidins (OPCs) (trade name) Classification Therapeutic: cardioprotective agents Chronic venous insufficiency, edema, diabetic retinopathy, varicose veins, cancer prevention, atherosclerosis, cirrhosis, prevention of collagen breakdown, vision problems, constipation, antioxidant, wound healing.ActionGrape flavonoids have a wide range of effects including antioxidant, vasodilatory, antiplatelet, decreased superoxide production, free-radical removal and inhibition of collagenase.Therapeutic effectsReduced risk of coronary disease.Decreased skin and vasculature breakdown.PharmacokineticsAbsorption: Unknown.Distribution: Unknown.Metabolism and Excretion: Unknown.Half-life: Unknown.Time/action profile | ONSET | PEAK | DURATION |
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PO | Unknown | Unknown | Unknown |
Contraindications/PrecautionsContraindicated in: Hypersensitivity or allergy to grape seed extract; Patients with bleeding disorders or receiving anticoagulant therapy.Use Cautiously in: Obstetric: Avoid use in pregnancy due to lack of safety data.Adverse Reactions/Side EffectsCardiovascularCentral nervous systemDermatologicEar, Eye, Nose, ThroatGastrointestinalHematologicInteractionsMay ↑ anticoagulant effects of warfarin.May ↓ plasma levels of CYP1A2 substrates.May inhibit the growth of lactobacillus acidophilus.May ↑ BP in hypertensive patients also takingvitamin c.Oral (Adults) 75–300 mg daily.AvailabilityTablets : Capsules: Nursing implicationsNursing assessment- Monitor BP periodically during therapy.
- Lab Test Considerations: Monitor serum cholesterol levels periodically during therapy.
Potential Nursing DiagnosesActivity intolerance (Indications)
Implementation- Administer as directed. Doses may vary.
Patient/Family Teaching- Advise patient not to take grape seed extract with Vitamin C; may cause increase in BP.
- Advise female patients to notify health care professional if pregnancy is planned or suspected.
Evaluation/Desired Outcomes- Decrease in cholesterol.
- Decrease in BP.
grape seed extract Abbreviation: GSE An extract of antioxidant oils isolated from the seeds of grapes (Vitis vinifera) and promoted by alternative and complementary medical practitioners as a potential treatment for coronary artery disease, cancer, and other illnesses produced or worsened by oxidative stresses on body tissues. The extract has been used as a traditional European remedy for diseases of the eyes and skin seems to reduce postoperative swelling faster than placebo. Scientific evidence for its clinical effectiveness is sparse. See also: extractLegalSeeExtractFinancialSeeGSE |