alpha-2-macroglobulin


alpha-2-macroglobulin

Alpha-2-M, antiplasmin An 800 kD protein, which maps to chromosome 12 which inhibits proteases–trypsin, chymotrypsin, elastase, thrombin, plasmin Ref range 125–420 mg/dL, higher in ♀ ↑ A2M Liver disease, DM, nephrotic syndrome, neural tube defects, ↑ estrogen, pregnancy, neonates and children, ataxia-telangiectasia ↓ A2M Protein-losing gastroenteropathy, protein malnutrition, DIC, fibrinolytic therapy