anergy
anergy
(ˈænədʒɪ)anergy
2. the failure of the body to respond to an allergen or antigen.
| Noun | 1. |  anergy - reduction or lack of an immune response to a specific antigen |
| 2. |  anergy - inactivity and lack of energy |
| 单词 | anergy | ||||||
| 释义 | anergyanergy(ˈænədʒɪ)anergy2. the failure of the body to respond to an allergen or antigen.
anergyanergy[an´er-je]an·er·gy(an'er-jē),anergyDepression or absence of an immune response to an antigen to which a host was previously sensitive. Anergy is characterised by decreased or absent lymphokine secretion by viable T cells when the T cell receptor is engaged by an antigen; it can be tested by loss of delayed hypersensitivity (e.g., to PPD, Candida antigens or DCNB).Anergy can be induced in mature and differentiated CD4+ T cells by exposure to complexes of antigen and appropriate (self) MHC in absence of certain uncharacterised co-stimulatory signals on the antigen-presenting cells. In patients who have received blood transfusions, anergy may be induced by presentation of antigen by “nonprofessional” antigen-presenting cells. anergyImmunology Depression or absence of an immune response to an antigen to which the host was previously sensitive; it is characterized by ↓/absent lymphokine secretion by viable T cells when the T cell receptor is engaged by an antigen; it can be tested by loss of delayed hypersensitivity–eg, to PPD, Candida antigens, or DCNB. See Clonal anergy, Deletion. Cf Allergy.an·er·gy(an'ĕr-jē)anergySpecific immunological tolerance in which T cells and B cells fail to respond normally by producing an immune response to antigens. The state can be reversed.anergyloss or weakening of the immune response to an irritating agent or ANTIGEN. A T-CELL that encounters an antigen and does not respond to it is anergic. Contrasts with ALLERGY where there is an overreaction, rather than lack of reaction, to a substance.an·er·gy(an'ĕr-jē)anergy
Words related to anergy
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