hypoxanthine phosphoribosyltransferase


hy·po·xan·thine phos·pho·ri·bo·syl·trans·fer·ase

an enzyme present in human tissue that catalyzes the conversion of hypoxanthine and guanine to their respective 5' nucleotides, with 5-phosphoribose 1-diphosphate as the ribose-phosphate donor; a partial deficiency of this enzyme can result in elevated purine biosynthesis leading to gout; another level of deficiency is associated with Lesch-Nyhan syndrome. Synonym(s): hypoxanthine guanine phosphoribosyltransferase