hemophilia

n (Pathology) an inheritable disease, usually affecting only males but transmitted by women to their male children, characterized by loss or impairment of the normal clotting ability of blood so that a minor wound may result in fatal bleeding ˌhaemoˈphiliˌoid, ˌhemoˈphiliˌoid adj

hemophilia, haemophilia

a tendency to uncontrolled bleeding. Also hemorrhaphilia, haemorrhaphilia. — hemophiliac, haemophiliac, n., adj.See also: Blood and Blood Vessels

an hereditary tendency, in males, toward a deficiency in coagulation factors in the blood. — hemophiliac, haemophiliac, n., adj.See also: Disease and Illness

Thesaurus

Noun

haemophilia - congenital tendency to uncontrolled bleeding; usually affects males and is transmitted from mother to sonbleeder's disease, hemophiliaclassical haemophilia, classical hemophilia, haemophilia A, hemophilia A - hemophilia caused by a congenital deficiency of factor VIII; occurs almost exclusively in menChristmas disease, haemophilia B, hemophilia B - a clotting disorder similar to hemophilia A but caused by a congenital deficiency of factor IXangiohemophilia, vascular hemophilia, von Willebrand's disease - a form of hemophilia discovered by Erik von Willebrand; a genetic disorder that is inherited as an autosomal recessive trait; characterized by a deficiency of the coagulation factor and by mucosal bleedingblood disease, blood disorder - a disease or disorder of the bloodsex-linked disorder - any disease or abnormality that is determined by the sex hormones; "hemophilia is determined by a gene defect on an X chromosome"

Translations

haemophilia

he·mo·phil·i·a

(hē'mō-fil'ē-ă) An inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhages, spontaneous or traumatic, due to a defect in the blood coagulating mechanism.
Synonym(s): haemophilia. [hemo- + G. philos, fond]

haemophilia

An X-linked recessive blood clotting disorder causing a life-long tendency to excessive bleeding. It cannot be passed from father to son because the father transmits only the Y chromosome to his sons. All the daughters of a haemophilic man are carriers of the gene but do not suffer the disease. There is a 50% chance that each of their sons will be a haemophiliac. Females can acquire the disease only if both X chromosomes carry the gene. Haemophilia A is due to the absence of Factor VIII, one of the coagulation factors. Haemophilia B (Christmas disease) is due to deficiency of Factor IX. Both feature bleeding, either spontaneous or on minor trauma, most commonly into the joints. This causes severe pain, swelling and muscle spasm. Repeated episodes lead to damage and severe joint disability. Tooth extraction or external injury are followed by prolonged bleeding. Spontaneous bleeding may occur into the bowel. Haemophilia is treated by repeated injections of Factor VIII or IX obtained from donated blood.

haemophilia

a rare human blood disorder in which BLOOD CLOTTING is deficient, resulting often in severe bleeding internally and externally. The condition is due to a lack of fibrin in the blood and is controlled by two closely linked genes on the X-CHROMOSOME that are responsible for the production of different clotting factors. Haemophilia A individuals lack antihaemophilic globulin (AHG) while haemophilia B individuals lack plasma thromboplastin. Males carrying the mutant ALLELE of either locus or (much more rarely) females homozygous for the recessive mutant alleles of either locus will be affected, although heterozygous females have normal blood. Haemophilia A is by far the most common form of the disease (about 80%) and can be treated by transfusions of AHG.

he·mo·phil·i·a

(hē'mō-fil'ē-ă) Inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhages, spontaneous or traumatic, because of a defect in the blood-coagulating mechanism.
Synonym(s): haemophilia. [hemo- + G. philos, fond]

haemophilia

Related to haemophilia: Haemophilia C

noun

Synonyms for haemophilia

noun congenital tendency to uncontrolled bleeding

Synonyms

bleeder's disease
hemophilia

Related Words

classical haemophilia
classical hemophilia
haemophilia A
hemophilia A
Christmas disease
haemophilia B
hemophilia B
angiohemophilia
vascular hemophilia
von Willebrand's disease
blood disease
blood disorder
sex-linked disorder