histrelin
histrelin
[his-trel´in]histrelin
(hiss-tre-lin) histrelin,Supprelin LA
(trade name),Vantas
(trade name)Classification
Therapeutic: hormonesPharmacologic: gonadotropin releasing hormones
Indications
Action
Therapeutic effects
Pharmacokinetics
Time/action profile (↓ in LH, FSH, and sex-steroid levels)
| ROUTE | ONSET | PEAK | DURATION |
| Subcut | unknown | 12 hr | 52 wk |
Contraindications/Precautions
Adverse Reactions/Side Effects
Central nervous system
- stroke (life-threatening)
- headache (most frequent)
- anxiety
- depression
- dizziness
- insomnia
- irritability
- lethargy
- malaise
- seizures
Ear, Eye, Nose, Throat
- visual disturbances
Respiratory
- dyspnea
Cardiovascular
- Myocardial infarction (life-threatening)
- vasodilation (most frequent)
- edema
- palpitations
- tachycardia
Gastrointestinal
- hepatotoxicity (life-threatening)
- abdominal discomfort
- constipation
- nausea
- vomiting
Genitourinary
- dysuria
- hematuria
- polyuria
- urinary retention
Dermatologic
- acne
- ↑ sweating
- pruritis
- rash
Endocrinologic
- breast discharge
- breast pain
- genital pruritis
- ↑ breast size
Hematologic
- anemia
Local
- itching, erythema, and swelling at implantation site (most frequent)
Metabolic
- hypercalcemia
- hyperglycemia
- hyperlipidemia
Musculoskeletal
- arthralgia
- bone pain
- joint stiffness
- muscle cramps
- muscle stiffness
- myalgia
Neurologic
- tremor
Miscellaneous
- allergic reactions including angioedema (life-threatening)
- hot flashes (most frequent)
- ↑ appetite
- ↑ pain
Interactions
Drug-Drug interaction
Unknown.Route/Dosage
Prostate Cancer
Central Precocious Puberty
Availability
Nursing implications
Nursing assessment
- Obtain a complete physical and endocrinologic examination, including height, weight, before starting, after 3 mo and every 6–12 mo during therapy.
- Assess for signs of disease progression periodically throughout therapy.
- Monitor patient for signs of hypersensitivity (angioedema, urticaria, hypotension, tachycardia, loss of consciousness, bronchospasm, dyspnea, flushing, pruritus). Discontinue therapy if any of these symptoms occur.
- Lab Test Considerations: Monitor LD, FSH, estradiol, or testosterone at 1 mo after implantation and every 6 mo thereafter.
- May cause ↑ AST and LDH; usually reversible with removal of implant.
Potential Nursing Diagnoses
Sexual dysfunction (Indications)Deficient knowledge, related to medication regimen (Patient/Family Teaching)
Implementation
- Subcutaneous: Histrelin is given as a single yearly subcutaneous implant. The implant must be removed after 12 mo of therapy. Subsequent implantation may be used to continue therapy.
Patient/Family Teaching
- Instruct patient to not to get arm wet for 24 hrs and to avoid strenuous lifting for 7 days after insertion.
- Inform patient and family that if implants are not given yearly, disease may progress.
- Advise patient and family that during initial agonistic phase (1–3 wk) the patient may have transient symptom worsening or onset of new symptoms, including bone pain, neuropathy, hematuria, or urinary tract obstruction.
- Inform patient and family that redness or swelling may occur at the implantation site, especially after initial implantation or implant removal. Notify health care professional if this reaction is severe or does not go away.
- Instruct patient and family to contact health care professional at the first sign of skin rash, urticaria, rapid heartbeat, difficulty swallowing or breathing, or any swelling that may suggest angioedema.
Evaluation/Desired Outcomes
- Palliation of signs and symptoms associated with prostate cancer.
- Delay of early onset of puberty.