human leukocyte antigens


hu·man leuko·cyte an·ti·gens (HLA),

[MIM*142560] system designation for the major histocompatibility complex gene products of at least four linked loci (A, B, C, and D) and a number of subloci on the sixth human chromosome that have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, immune responsiveness to certain antigens, and certain disease associations; autosomal dominant inheritance. See: major histocompatibility complex.

human leukocyte antigens

See HLA.

hu·man leu·ko·cyte an·ti·gens

(HLA) (hyū'măn lū'kō-sīt an'ti-jen) Any of several members of a system consisting of the gene products of at least four linked loci (A, B, C, and D) and a number of subloci on the sixth human chromosome that have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, and certain disease associations; more than 50 alleles are recognized, most of which are at loci HLA-A and HLA-B; autosomal dominant inheritance.