| Acronym | Definition |
|---|
| HLE➣High Level Event |
| HLE➣Hertz Local Edition |
| HLE➣Healthy Life Expectancy |
| HLE➣Humane Law Enforcement (American Society for the Prevention of Cruelty to Animals and New York City Police Department) |
| HLE➣Holy Land Experience (Christian exhibit and museum; Orlando, FL) |
| HLE➣Home Learning Environment (early education) |
| HLE➣Higher Layer Entity (computing) |
| HLE➣High Level Estimate |
| HLE➣Half-Life Elite (gaming, Half-Life modification) |
| HLE➣Houston Language Emulator |