interleukin-10

in·ter·leu·kin-10

(in'tĕr-lū'kin), A cytokine derived from helper T-cell lymphocytes (Th₂) that inhibits γ-interferon (IFNγ) and IL-2 secretion by T-cell lymphocytes (Th₁) and inhibits mononuclear cell inflammation.

IL10

A gene on chromosome 1q31-q32 that encodes interleukin-10, a cytokine produced primarily by monocytes, but also by lymphocytes, which inhibits the synthesis of a number of cytokines (including IFN-gamma, IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and helper T cells. IL10 has pleiotropic effects in immunoregulation and inflammation. It downregulates expression of Th1 cytokines, MHC class-II antigens and co-stimulatory molecules on macrophages, and it enhances B cell survival, proliferation and antibody production. It can block NF-kappa B activity, and is involved in regulating the JAK-STAT signalling pathway.
Molecular pathology
IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

in·ter·leu·kin-10

(in'tĕr-lū'kin) A cytokine derived from helper T-cell lymphocytes, B-cell lymphocytes, and monocytes that inhibits interferon gamma; (IFNγ) secretion by T-cell lymphocytes and it inhibits mononuclear cell inflammation.

interleukin-10

A CYTOKINE produced by helper T cells, B cells, MACROPHAGES, and the placenta that inhibits gamma-interferon secretion and mononuclear cell inflammation.

单词	interleukin-10
释义	DictionarySeeinterleukin interleukin-10 interleukin-10 [‚in·tər¦lük ′ten] (immunology) An immunoregulatory cytokine produced by a subset of helper T cells as well as by B lymphocytes and some cells of the uterus during pregnancy, it inhibits secretion (and function) of cytokine by macrophages and the second population of helper T cells called Th1. Abbreviated IL-10. interleukin-10 in·ter·leu·kin-10 (in'tĕr-lū'kin), A cytokine derived from helper T-cell lymphocytes (Th₂) that inhibits γ-interferon (IFNγ) and IL-2 secretion by T-cell lymphocytes (Th₁) and inhibits mononuclear cell inflammation. IL10 A gene on chromosome 1q31-q32 that encodes interleukin-10, a cytokine produced primarily by monocytes, but also by lymphocytes, which inhibits the synthesis of a number of cytokines (including IFN-gamma, IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and helper T cells. IL10 has pleiotropic effects in immunoregulation and inflammation. It downregulates expression of Th1 cytokines, MHC class-II antigens and co-stimulatory molecules on macrophages, and it enhances B cell survival, proliferation and antibody production. It can block NF-kappa B activity, and is involved in regulating the JAK-STAT signalling pathway. Molecular pathology IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. in·ter·leu·kin-10 (in'tĕr-lū'kin) A cytokine derived from helper T-cell lymphocytes, B-cell lymphocytes, and monocytes that inhibits interferon gamma; (IFNγ) secretion by T-cell lymphocytes and it inhibits mononuclear cell inflammation. interleukin-10 A CYTOKINE produced by helper T cells, B cells, MACROPHAGES, and the placenta that inhibits gamma-interferon secretion and mononuclear cell inflammation.
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