单词 | interleukin-13 |
释义 | interleukin-13interleukin-13[‚in·tər¦lük·ən ′thər‚tēn]interleukin-13in·ter·leu·kin-13(in'tĕr-lū'kin),IL13A gene on chromosome 5q31 that encodes interleukin-13, an immunoregulatory cytokine produced primarily by activated Th2 cells which is involved in B-cell maturation and differentiation. IL13 upregulates CD23 and MHC class II expression and promotes IgE isotype switching in B cells; it downregulates macrophage activity, inhibiting production of pro-inflammatory cytokines and chemokines.Molecular pathology IL-13 plays a central in the pathogenesis of allergen-induced asthma by IgE- and eosinophil-independent mechanisms. in·ter·leu·kin-13(in'tĕr-lū'kin)interleukin-13A CYTOKINE produced by T LYMPHOCYTES that inhibits mononuclear cell inflammation. |
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