| 单词 | interferon-alpha |
| 释义 | interferon-alphainterferon-alpha[‚in·tər¦fir·än ′al·fə]interferon-alphainterferon-alphaIFN-α Immunology A family of 20 leukocyte-derived immunomodulating glycoproteins with antiproliferative and antiviral activity Indications Recombinant IFN-α is used to treat hairy cell leukemia, CML, KS, HPV-related proliferations–eg, condyloma acuminatum, respiratory papillomatosis, pulmonary hemangioendotheliosis, chronic hepatitis–eg, HCV, as well as renal CA ±vinblastine, NHL, and to inhibit angiogenesis Side effects Flu-like Sx, malaise, fatigue, headache, anxiety, vertigo, depression, ↑ aminotransferase, BM suppression–granulocyte toxicity, SVT with hypotension or HTN, potentially fatal CHF, exacerbation of multiple sclerosis;1⁄2 of Pts, especially with cirrhosis and hypersplenism don't tolerate therapy because of fatigue, profound thrombocytopenia and neutropenia. See Angiogenesis inhibitors. |
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