| 单词 | interferon gamma |
| 释义 | interferon gammainterferon gammainterferon gammain·ter·fer·on gam·mainterferon gammaIFNGA gene on chromosome 12q14 that encodes a soluble cytokine belonging to the type-II interferon family that has antiviral, immunoregulatory and anti-tumour properties, and is a potent macrophage activator. It is produced by lymphocytes activated by specific antigens or mitogens.Molecular pathology Defects in IFNG is associated with increased susceptibility to aplastic anaemia in Caucasians. interferon gammaIFN-γ A 21-25 kD glycoprotein lymphokine encoded on chromosome 12q and produced by activated T and NK cells; IFN-γ is antiviral, regulates class II MHC antigen expression, Fc receptors and immunoglobulin production and class switching, activates monocyte cytotoxicity and enhances NK cell activity; IFN-γ is ↓ in IgA deficiency, lymphoma, CLL, infections–eg, CMV, EBV, rubella, lepromatous leprosy, TB, SLE, rheumatoid arthritis, sickle cell anemia, post-transplantation Indications Recombinant IFN-γ is used to treat condylomata acuminata, CLL, Hodgkin's disease, mycosis fungoides, rheumatoid arthritis, and possibly leprosy, TB, nontuberculous mycobacterial infections, toxoplasmosis, chronic granulomatous disease–to prevent infections; IFN-γ suppresses collagen synthesis by fibroblasts, ↓ the size of keloids, causing a local ↑ in inflammatory cells and mucin production, and may be of use in controlling abnormal fibrosing conditions Side effects Acute renal failure, rash, headache, chillsin·ter·fer·on gam·ma(intĕr-fēron gamă)Synonym(s): antigen interferon, immune interferon. interferon gammaAn INTERFERON used as an antiviral drug. A brand name is Immukin.in·ter·fer·on gam·ma(intĕr-fēron gamă) |
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