单词 | apolipoprotein |
释义 | apolipoproteinap·o·lip·o·pro·teinA0368850 (ăp′ə-lĭp′ō-prō′tēn′, -tē-ĭn, -lī′pō-)apolipoprotein(ˌæpəˌlɪpəʊˈprəʊtiːn; -ˌlaɪ-)apolipoproteinapolipoprotein[¦a·pō¦li·pō′prō‚tēn]apolipoproteinapolipoprotein[ap″o-lip″o-pro´tēn]ap·o·lip·o·pro·tein (apo),(ap'ō-lip'ō-prō'tēn),apolipoprotein(ăp′ə-lĭp′ō-prō′tēn′, -tē-ĭn, -lī′pō-)apolipoproteinAny of a family of small proteins on the surface of lipoprotein complexes, which bind to specific enzymes or transport proteins across cell membranes, which correspond to the protein moiety of lipoproteins. See HDL-cholesterol, Kringle domain.ap·o·lip·o·pro·tein(ap'ō-lip-ō-prō'tēn)apolipoproteinOne of a number of glycoproteins forming part of the surface of LIPOPROTEIN particles in the blood. Apolipoproteins are polar structures which provide structural stability to the lipoprotein and act as receptors that help to determine the fate of the particle. Some act as cofactors for enzymes involved in lipid and lipoprotein metabolism. The level of apolipoprotein-A is genetically induced and a high level is a strong risk factor for premature coronary heart disease. It is a feature of FAMILIAL HYPERCHOLESTEROLAEMIA. Apolipoprotein-B is the binding site of low-density lipoproteins (LDL) to cellular LDL receptors and is concerned in the movement of CHYLOMICRONS from the intestine. Apolipoprotein-C is present on chylomicrons, high-density lipoproteins and very low-density lipoproteins. Apolipoprotein-E genotyping has been used to predict the likelihood of ALZHEIMER'S DISEASE. |
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