insulin-dependent diabetes mellitus type 20

A disorder (OMIM:612520) of glucose homeostasis, which is characterised by susceptibility to ketoacidosis in the absence of insulin therapy.
Clinical findings
Polydipsia, polyphagia and polyuria due to hyperglycaemia-induced osmotic diuresis and secondary thirst. Long-term diabetic complications affect the eyes, kidneys, nerves and blood vessels.
Molecular pathology
Defects in HNF1A, which encodes a transcription activator that regulates tissue-specific expression of multiple genes, cause diabetes mellitus insulin-dependent type 20.

单词	insulin-dependent diabetes mellitus type 20
释义	insulin-dependent diabetes mellitus type 20 insulin-dependent diabetes mellitus type 20 A disorder (OMIM:612520) of glucose homeostasis, which is characterised by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical findings Polydipsia, polyphagia and polyuria due to hyperglycaemia-induced osmotic diuresis and secondary thirst. Long-term diabetic complications affect the eyes, kidneys, nerves and blood vessels. Molecular pathology Defects in HNF1A, which encodes a transcription activator that regulates tissue-specific expression of multiple genes, cause diabetes mellitus insulin-dependent type 20.
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