| 释义 |
insulinlike growth factor
in·su·lin·like growth factor I5189700 (ĭn′sə-lĭn-līk′)n. See somatomedin.insulinlike growth factor
in·su·lin·like growth factor (IGF), (formerly termed somatomedin C), the most important somatomedin for postnatal growth; it is produced in the liver, kidney, muscle, pituitary, the gastrointestinal tract, and chondrocytes. IGF-I is a basic protein (7600 MW) that circulates bound to six distinct IGF binding proteins (IGF-BPs), which increase the half-life of circulating IGF-I to 3-18 hours, as compared with the half-life of 20-30 minutes for unbound hormone. Local tissue generation of IGF-I/SM-C, particularly in bone, may play an important role in growth mediation through its paracrine effects. Synonym(s): somatomedinsin·su·lin·like growth fac·tor (IGF) (insŭ-lin grōth faktŏr) Most important somatomedin for postnatal growth; produced in the liver, kidney, and elsewhere. |