insulin receptor

INSR

A gene on chromosome 19p13.3-p13.2 that encodes insulin receptor, the binding of insulin to which stimulates glucose uptake.
Molecular pathology
Defects of INSR cause Rabson-Mendenhall syndrome, leprechaunism and hyperinsulinaemic hypoglycaemia type 5.

insulin receptor

A heterodimeric membrane receptor composed of α and
β chains, which has tyrosine kinase activity after binding insulin; IR deficiency is a rare cause of DM and may be due to a gene rearrangement, causing a deletion in the tyrosine kinase domain, a point mutation with a loss of the ATP binding site or other genetic defect

单词	insulin receptor
释义	insulin receptor INSR A gene on chromosome 19p13.3-p13.2 that encodes insulin receptor, the binding of insulin to which stimulates glucose uptake. Molecular pathology Defects of INSR cause Rabson-Mendenhall syndrome, leprechaunism and hyperinsulinaemic hypoglycaemia type 5. insulin receptor A heterodimeric membrane receptor composed of α and β chains, which has tyrosine kinase activity after binding insulin; IR deficiency is a rare cause of DM and may be due to a gene rearrangement, causing a deletion in the tyrosine kinase domain, a point mutation with a loss of the ATP binding site or other genetic defect See IR See INSR
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