inflammasome

A multiprotein cytoplasmic complex which activates one or more caspases, leading to the processing and secretion of pro-inflammatory cytokines—e.g., IL-1 beta, IL-18 and IL-33. Assembly of inflammasomes depends on the NOD-like receptor family members, such as the NALP proteins. The best studied of these pro-inflammatory protein complexes are NALP1 inflammasome and NALP3 inflammasome. Inflammasomes co-operate with Toll-like receptors to respond appropriately to pathogenic triggers and metabolic or genotoxic stresses, by processing interleukins and promoting the inflammatory response. Dysegulation or mutations in the genes’ encoding components of the inflammasome complex are associated with auto-immunity problems.

inflammasome

(in-flam′ă-sōm″) [ inflamma(tion) + -some] A cytoplasmic complex that regulates the activation of caspase enzymes, which convert interleukins from their inactive forms to active forms.

inflammasome

A complex of proteins found in macrophages and neutrophils with a fundamental role in the production of inflammation in innate immunity. The NALP 1 and NALP 3 members of the NALP family of proteins (nacht domain-, leucine-rich repeat-, and pyd-containing proteins) are the main components of the inflammasome. NAPL3 (cryopyrin) is the central element in the cryopyrin inflammasome. Activation of cryopyrin by bacteria or urate crystals (as in gout) sets off a cascade of events leading to inflammation.

单词	inflammasome
释义	inflammasome inflammasome A multiprotein cytoplasmic complex which activates one or more caspases, leading to the processing and secretion of pro-inflammatory cytokines—e.g., IL-1 beta, IL-18 and IL-33. Assembly of inflammasomes depends on the NOD-like receptor family members, such as the NALP proteins. The best studied of these pro-inflammatory protein complexes are NALP1 inflammasome and NALP3 inflammasome. Inflammasomes co-operate with Toll-like receptors to respond appropriately to pathogenic triggers and metabolic or genotoxic stresses, by processing interleukins and promoting the inflammatory response. Dysegulation or mutations in the genes’ encoding components of the inflammasome complex are associated with auto-immunity problems. inflammasome (in-flam′ă-sōm″) [ inflamma(tion) + -some] A cytoplasmic complex that regulates the activation of caspase enzymes, which convert interleukins from their inactive forms to active forms. inflammasome A complex of proteins found in macrophages and neutrophils with a fundamental role in the production of inflammation in innate immunity. The NALP 1 and NALP 3 members of the NALP family of proteins (nacht domain-, leucine-rich repeat-, and pyd-containing proteins) are the main components of the inflammasome. NAPL3 (cryopyrin) is the central element in the cryopyrin inflammasome. Activation of cryopyrin by bacteria or urate crystals (as in gout) sets off a cascade of events leading to inflammation.
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