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DictionarySeereactionEncyclopediaSeeReactionJarisch-Herxheimer reaction
Jarisch-Herxheimer reaction [yah´rish herks´hi-mer] a transient, short-term immunologic reaction commonly seen following antibiotic treatment of early and later stages of syphilis and less often in other diseases, such as borreliosis, brucellosis, typhoid fever, and trichinosis. Manifestations include fever, chills, headache, myalgias, and exacerbation of cutaneous lesions. The reaction has been attributed to liberation of endotoxin-like substances or antigens from the killed or dying microorganisms, but its exact pathogenesis is unclear.Herx·hei·mer re·ac·tion (herks'hī-mĕr), an inflammatory reaction in syphilitic tissues (skin, mucous membrane, nervous system, or viscera) induced in certain cases by specific treatment with arsphenamine (Salvarsan), mercury, or antibiotics; believed to be due to a rapid release of treponemal antigen with an associated allergic reaction in the patient. Synonym(s): Jarisch-Herxheimer reactionHerx·hei·mer re·ac·tion (herks'hīm-er rē-ak'shŭn) A systemic inflammatory reaction affecting the skin, mucous membranes, nervous system, or viscera occurring after antimicrobial treatment of treponemal disease (e.g., syphilis, Lyme disease); believed to be due to a rapid release of treponemal antigen with an associated allergic reaction in the patient.
Synonym(s): Jarisch-Herxheimer reaction. Jarisch-Herxheimer reaction A sudden acute feverish reaction, often associated with a flare-up of a skin rash, sometimes occurring within hours of beginning treatment of SYPHILIS, LEPTOSPIROSIS or RELAPSING FEVER with penicillin. The reaction is thought to be caused by allergy to some of the products of destroyed spirochaetes. (Adolf Jarisch, 1850–1902, Austrian dermatologist; and Karl Herxheimer, 1861–1944, German dermatologist).Jarisch-Herxheimer reactionA temporary reaction to penicillin treatment for syphilis that includes fever, chills, and worsening of the skin rash or chancre.Mentioned in: Leptospirosis, SyphilisHerxheimer, Karl, German dermatologist, 1861-1944. Herxheimer reaction - an inflammatory reaction in syphilitic tissues induced by specific treatment with Salvarsan, mercury, or antibiotics. Synonym(s): Jarisch-Herxheimer reactionHerxheimer spiralJarisch-Herxheimer reaction - Synonym(s): Herxheimer reaction
Jarisch, Adolf, Austrian dermatologist, 1850-1902. Bezold-Jarisch reflex - see under Bezold, Albert vonJarisch-Herxheimer reaction - Synonym(s): Herxheimer reactionHerx·hei·mer re·ac·tion (herks'hīm-er rē-ak'shŭn) Inflammatory reaction in patients with syphilis induced in some cases by treatment with some drugs.
Synonym(s): Jarisch-Herxheimer reaction. |