intramembranous bone formation

Bone formation that occurs without a prior cartilage model, which contrasts to enchondral ossification.
Examples
Embryonic flat bone formation—e.g., skull, maxilla, mandible, pelvis, clavicle, subperiosteal surface of long bone; distraction osteogenesis bone formation; blastem bone (occurs in children following amputations); fracture healing with rigid fixation (e.g., with a compression plate); may occur as a component of healing with intramedullary nailing.
Defects in intramembranous bone formation
Caused by mutation in RUNX2 located on chromosome 6.
Steps of intramembranous bone formation
• Aggregation of undifferentiated mesenchymal cells;
• Osteoblast differentiation;
• Organic matrix deposition.

单词	intramembranous bone formation
释义	intramembranous bone formation intramembranous bone formation Bone formation that occurs without a prior cartilage model, which contrasts to enchondral ossification. Examples Embryonic flat bone formation—e.g., skull, maxilla, mandible, pelvis, clavicle, subperiosteal surface of long bone; distraction osteogenesis bone formation; blastem bone (occurs in children following amputations); fracture healing with rigid fixation (e.g., with a compression plate); may occur as a component of healing with intramedullary nailing. Defects in intramembranous bone formation Caused by mutation in RUNX2 located on chromosome 6. Steps of intramembranous bone formation • Aggregation of undifferentiated mesenchymal cells; • Osteoblast differentiation; • Organic matrix deposition.
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