intravascular lymphomatosis

intravascular large B-cell lymphoma

A high-grade non-Hodgkin lymphoma arising in and generally confined to vascular lumina, which usually begins in the skin and CNS and rapidly spreads elsewhere.
Clinical findings
Often begins with fever of unknown origin and nonspecific cutaneous (e.g., plaques) and neurologic complaints.

DiffDx
Skin lesions (erythematous/purple plaques on the trunk and lower legs) may be confused with mycosis fungoides, sarcoidosis, vascular neoplasms (e.g., Kaposi sarcoma) or involvement by lymphoma or leukaemia.
Prognosis
Extremely poor; short survival is the norm despite aggressive chemotherapy. The diagnosis is often established postmortem.

intravascular lymphomatosis

Angiotropic large cell lymphoma, malignant angioendotheliomatosis, neoplastic angioendotheliomatosis Oncology A lymphoma in which the lymphocytes home to vascular endothelium, possibly related to expression of specific lymphocyte-endothelium adhesion molecules Prognosis Poor; most die, often before diagnosis

单词	intravascular lymphomatosis
释义	intravascular lymphomatosis intravascular large B-cell lymphoma A high-grade non-Hodgkin lymphoma arising in and generally confined to vascular lumina, which usually begins in the skin and CNS and rapidly spreads elsewhere. Clinical findings Often begins with fever of unknown origin and nonspecific cutaneous (e.g., plaques) and neurologic complaints. DiffDx Skin lesions (erythematous/purple plaques on the trunk and lower legs) may be confused with mycosis fungoides, sarcoidosis, vascular neoplasms (e.g., Kaposi sarcoma) or involvement by lymphoma or leukaemia. Prognosis Extremely poor; short survival is the norm despite aggressive chemotherapy. The diagnosis is often established postmortem. intravascular lymphomatosis Angiotropic large cell lymphoma, malignant angioendotheliomatosis, neoplastic angioendotheliomatosis Oncology A lymphoma in which the lymphocytes home to vascular endothelium, possibly related to expression of specific lymphocyte-endothelium adhesion molecules Prognosis Poor; most die, often before diagnosis
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