ISD

Abbreviation for intrinsic sphincter deficiency.

deficiency

(di-fish'en-se) [L. deficere, to lack] Less than the normal amount; a lack.

acid lipase deficiency

One of two autosomal recessive illnesses in which the body lacks an enzyme for metabolizing fats, causing cholesterol, oils, or waxes to accumulate in abnormal amounts in the body. The acid lipase diseases are Wolman disease and cholesterol ester storage disease. Synonym: acid lipase diseaseAcid lipase disease.

antithrombin-III deficiency

An inherited hypercoagulable state. It is due to absent or deficient levels of antithrombin III in the blood. Synonym: hereditary thrombophilia

aspartoacylase deficiency

Canavan disease.

biotinidase deficiency

An autosomal recessive disease in which affected children fail to metabolize biotin effectively. Seizures, encephalopathy, neurodevelopmental delay, spasticity or diminished muscle tone, paresis, visual disturbances, deafness, skin rash, and hair loss commonly occur. Immediate ongoing treatment with supplemental biotin can effectively suppress the symptoms of this disease.

branching enzyme deficiency

Type IV glycogen storage disease.

ceramidase deficiency

Farber disease.

color deficiency

See: color blindness

color vision deficiency

See: color blindness

copper deficiency

The clinical consequences of inadequate consumption or absorption of dietary copper. Its hallmarks include an unsteady gait, neuropathy, muscle spasticity, and, occasionally, anemia. It may occur as a consequence of gastric bypass surgery or long-term parenteral nutrition.

delta storage pool deficiency

Dense granule deficiency syndrome.

functional iron deficiency

A deficiency of iron significant enough to affect the development of healthy red blood cells. It may precede the appearance of measurable anemia.

Patient care

Functional iron deficiency may be defined by the presence of hypochromatic red cells; by an increase in hemoglobin production after test doses of administered iron; or, most accurately, by the measurement of the mean hemoglobin content of reticulocytes. It is common in patients receiving hemodialysis and in critically ill persons.

Treatment

Treatments include iron and folate supplements and epoetin alpha (Procrit) to increase red blood cell production. In emergencies, infusion of fresh frozen packed cells or washed packed cells provide temporary relief.

glucose-6-phosphate dehydrogenase deficiency

An X-linked disorder affecting the red blood cells. It is present in the U.S. in about 13% of black males and 2% of black females. The deficiency also occurs in Arab, Mediterranean, and Asian populations. The enzyme is essential to maintaining the integrity of erythrocytes; thus a deficiency of it causes nonimmune hemolytic anemia. There are many variants of the enzyme and great variation in severity of the disease. Some people do not have clinical symptoms until they are exposed to certain drugs (such as antimalarials, antipyretics, sulfonamides) or to fava beans, or when they contract an infectious disease. In others the condition is present at birth. When present at birth, anemia, hepatomegaly, hypoglycemia, and interference with growth are present. In those who have the deficiency but are not affected until exposed to certain drugs or infections, hemolytic anemia and jaundice occur.

Diagnosis

Laboratory tests for evidence of the enzyme deficiency are available.

Treatment

The only treatment is avoidance of drugs known to cause hemolysis and avoidance of fava beans if the person is known to be sensitive to them.

immune deficiency

Immunodeficiency.

intrinsic sphincter deficiency

Abbreviation: ISD
Weakening of the urethral sphincter muscles, a frequent cause of stress urinary incontinence.

leukocyte adhesion deficiency

Abbreviation: LAD
A rare autosomal recessive disorder in which white blood cells are unable to migrate out of blood vessels in response to infection. It often presents in early childhood with severe periodontal disease, premature loss of teeth, and recurrent infections.

medium-chain acyl-CoA dehydrogenase deficiency

Abbreviation: MCADD
An inherited disorder of faulty nutrient oxidation in which affected infants are unable to metabolize fatty acids when their stores of blood glucose are low, e.g., between meals. The disease is common, occurring in 1 in 10,000 infants, and often fatal in infancy. Surviving infants may suffer brain damage from inadequate nutrition to the central nervous system during fasts.

mental deficiency

See: mental retardation

muscle phosphorylase deficiency

McArdle disease

ornithine transcarbamylase deficiency

The most common urea cycle enzyme deficiency disorder inherited as an autosomal recessive trait, characterized by the absence of ornithine transcarbamylase (an enzyme in the urea cycle), which results in the excessive buildup of ammonia in the bloodstream. The disease is typically diagnosed in infancy and occurs in less than 1 in 8000 births.

phosphofructokinase deficiency

Abbreviation: PFKM
A glycogen storage disease caused by a deficiency of muscle phosphofructokinase and characterized by muscular weakness, and muscle cramps after exercise, hemolysis, hyperuricemia, and myoglobinuria. Synonym: glycogen storage disease type VII; Tarui disease

deficiency of sweating

Anhidrosis.

ZAP70 deficiency

Zeta-chain associated protein kinase deficiency.

zeta-chain associated protein kinase 70kDa deficiency

Abbreviation: ZAP70 deficiency
A severe combined immunodeficiency disease in which CD8+ T cells are missing from the circulation and the thymus develops abnormally.

intrinsic sphincter deficiency

Abbreviation: ISD
Weakening of the urethral sphincter muscles, a frequent cause of stress urinary incontinence. See also: deficiency

ISD

Acronym	Definition
ISD➣Independent School District
ISD➣Intermediate School District
ISD➣Information Services Division
ISD➣Instructional Systems Design
ISD➣Independent Sales Director
ISD➣Infrastructure Services Division (US FEMA)
ISD➣Intergemeentelijke Sociale Dienst (Dutch: Inter-Municipal Social Services)
ISD➣Infrastructure Services Department (various organizations)
ISD➣Infrastructure Service Delivery
ISD➣Information Systems Development
ISD➣Information Systems Division
ISD➣Intel Security Driver
ISD➣Information Systems Department
ISD➣Interactive Source Debugger
ISD➣Investment Services Directive (Europe)
ISD➣Information Services Department
ISD➣Investor-State Dispute (international arbitration)
ISD➣Illinois School for the Deaf
ISD➣Issaquah School District (Washington)
ISD➣Institute for Sustainable Design (various schools)
ISD➣Inherently Safer Design (engineering practice)
ISD➣Inspectional Services Department
ISD➣Insurance Services Division (various organizations)
ISD➣Integrated Services Digital
ISD➣Intrinsic Sphincter Deficiency
ISD➣International Students' Day (November 17)
ISD➣Internal Security Department (Singapore)
ISD➣Individual Skill Development
ISD➣Issuer Security Domain
ISD➣Indiana School for the Deaf
ISD➣In Service Date
ISD➣Integrated Service Delivery (American Red Cross)
ISD➣Instructional System Development (US Air Force Air Education and Training Command AETC AFI)
ISD➣Inhibited Sexual Desire
ISD➣In-School Detention
ISD➣Integrated Systems Development
ISD➣In-System Diagnostics (Kozio)
ISD➣Investor Services Department (Housing Development Fund Corporation)
ISD➣Inspectional Services Division (various locations)
ISD➣Iowa School for the Deaf
ISD➣International Subscriber Dialing
ISD➣International Service Director
ISD➣Identical Sibling Donor
ISD➣Imperial-class Star Destroyer (Star Wars)
ISD➣Information System Department
ISD➣International Society of Differentiation
ISD➣Inter-Allied Services Department
ISD➣Image Safe Data
ISD➣Imperator-Class Star Destroyer (Star Wars)
ISD➣Image Section Descriptor
ISD➣Information Systems Directorate
ISD➣Integrated Self-Defense (US DoD)
ISD➣Independent Sealing Distributors
ISD➣Industrial Service Division (various organizations)
ISD➣Institute for Spinal Disorders (Los Angeles, CA)
ISD➣International School of Dakar (Senegal)
ISD➣Interim Status Document
ISD➣Information Storage Device (electronics)
ISD➣Integrated System Diagnostics, Inc.
ISD➣Isuzu Sales Deutschland GmbH (Germany)
ISD➣Institute of Social Development (est. 1991; Sri Lanka)
ISD➣Implied Standard Deviation
ISD➣International Standards Development
ISD➣Interface Summary Design
ISD➣Incremental Software Development
ISD➣Inter-Satellite Distance
ISD➣Immune System Disorder
ISD➣International Skill Development, Inc.
ISD➣Image Support Data
ISD➣Independent Segment Decoding
ISD➣Innovativ Systems Design (Edison, NJ)
ISD➣Ignition Safety Device
ISD➣Installation Supply Division
ISD➣Industrie-Sprachen-Dienst (Stuttgart, Germany language courses)
ISD➣In Striking Distance
ISD➣Installation Support Division (US Army Corps of Engineers)
ISD➣Interactive Software Development
ISD➣India Development Centre
ISD➣Integrated Services Director
ISD➣Internal Stability Division (South Africa)
ISD➣Interim Situation Display
ISD➣In-flight Service Director
ISD➣Implementation Support and Development (International Civil Aviation Organization)
ISD➣Internet Security Device
ISD➣Institut für Statik und Dynamik, Leibniz Universität Hannover
ISD➣Itakura-Saito Distortion
ISD➣International Systems Development
ISD➣Integrated Solutions Development (Sprint)
ISD➣Intelligent Storage Device (area network environment)
ISD➣Initial Search Depth
ISD➣Internal Symbol Dictionary
ISD➣Ion Stimulated Desorption
ISD➣Installation Specific Data
ISD➣Individual Soldier Detector
ISD➣Implantable Stimulation Device (cardiology)
ISD➣Intelligence Support Detachment (USFK specific)
ISD➣Interference Suppression Devices
ISD➣Incidental Sequences Diagram
ISD➣Infrared Suppression Device
ISD➣Information Systems Designator/Directive
ISD➣Idle Signal Detected
ISD➣Instructional Systems Development Design
ISD➣International Standard Data Network
ISD➣Internet Software Design
ISD➣Intersite Delivering
ISD➣Integrated Services Document
ISD➣Intradiscal Stabilization Device
ISD➣Independent Sydney and Districts Schools Sports Association (Australia)
ISD➣Intelligence Shared Database
ISD➣Interface Structure Diagram
ISD➣Information System Display
ISD➣International Switched Data
ISD➣Intersystem Designation
ISD➣Interoperability and Standardization Director
ISD➣Islamic Society of Denton (Texas)