Jamaican vomiting sickness

ack·ee poi·son·ing

an acute and frequently fatal vomiting disease associated with central nervous system symptoms and marked hypoglycemia, caused by eating unripe ackee fruit of Blighia spaida, a tree common in Jamaica. Synonym(s): Jamaican vomiting sickness

Jamaican vomiting sickness

An intoxication by “bush tea” made from unripe fruit of the Jamaican ackee tree (Blighia sapida), which is caused by hypoglycin, a propionic acid derivative that inhibits isovaleryl CoA dehydrogenase, provoking violent vomiting, prostration, drowsiness, convulsions and hypoglycaemia as low as 0.56 mmol/L (US: 10 mg/dl).

Mortality
High; death often occurs within 24 hours of ingestion.

Pathogenesis
The condition is caused by the metabolites of hypoglycin A, an amino acid that is converted to coenzyme A thioesters and carnitine derivatives; these sequester intracellular carnitine and inhibit fatty acid oxidation, causing accumulation of isovaleric acid with continued fatty acid esterification, resulting in fine-droplet fatty liver.

Jamaican vomiting sickness

An intoxication by 'bush tea,' made from unripe fruit of the Jamaican ackee tree–Blighia sapida and Crotalaria spectabilis, caused by hypoglycin A metabolites Clinical Violent vomiting, prostration, drowsiness, convulsions, hypoglycemia Mortality High, often 24 hrs after ingestion

单词	jamaican vomiting sickness
释义	Jamaican vomiting sickness ack·ee poi·son·ing an acute and frequently fatal vomiting disease associated with central nervous system symptoms and marked hypoglycemia, caused by eating unripe ackee fruit of Blighia spaida, a tree common in Jamaica. Synonym(s): Jamaican vomiting sickness Jamaican vomiting sickness An intoxication by “bush tea” made from unripe fruit of the Jamaican ackee tree (Blighia sapida), which is caused by hypoglycin, a propionic acid derivative that inhibits isovaleryl CoA dehydrogenase, provoking violent vomiting, prostration, drowsiness, convulsions and hypoglycaemia as low as 0.56 mmol/L (US: 10 mg/dl). Mortality High; death often occurs within 24 hours of ingestion. Pathogenesis The condition is caused by the metabolites of hypoglycin A, an amino acid that is converted to coenzyme A thioesters and carnitine derivatives; these sequester intracellular carnitine and inhibit fatty acid oxidation, causing accumulation of isovaleric acid with continued fatty acid esterification, resulting in fine-droplet fatty liver. Jamaican vomiting sickness An intoxication by 'bush tea,' made from unripe fruit of the Jamaican ackee tree–Blighia sapida and Crotalaria spectabilis, caused by hypoglycin A metabolites Clinical Violent vomiting, prostration, drowsiness, convulsions, hypoglycemia Mortality High, often 24 hrs after ingestion See JVS See JVS
随便看	leadership for healthy communities leadership for learning leadership for life network leadership for quality education leadership for results leadership for the common good leadership foundation for higher education leadership, friendship, service leadership, governance and management leadership governance and management fund leadership greater little rock leadership greater new haven leadership group executive search leadership health care leadership, honor, courage leadership idaho agriculture leadership in action leadership in diversity and communications leadership in ecology, culture and learning leadership in education about alcohol and drugs leadership in educational and sport organizations leadership in education program leadership in energy and environmental design leadership in energy and environmental design for existing buildings leadership in energy and environment design