base excision repair

[′bās ek′siz·zhən ri‚per] (cell molecular) A deoxyribonucleic acid (DNA) repair system in which an altered base is removed from the sugar backbone by action of a specific DNA glycolase and then the abasic sugar is removed by apurinic/apyrimidic (AP) lyase and AP endonuclease, leaving a one-nucleotide gap that is then filled in and ligated.

base excision repair

A mechanism that repairs damaged DNA during the cell cycle by removing small, non-helix-distorting nucleotide base lesions, which could otherwise cause mutations by mispairing or lead to breaks in DNA during replication. BER is initiated by DNA glycosylases that recognise and remove damaged or inappropriate bases, forming AP sites which are then cleaved by an AP endonuclease. The single-strand break formed by AP endonuclease are then processed by either short-patch (a single nucleotide is replaced), or long-patch (2–10 new nucleotides are synthesised) repair.

单词	base excision repair
释义	base excision repair base excision repair [′bās ek′siz·zhən ri‚per] (cell molecular) A deoxyribonucleic acid (DNA) repair system in which an altered base is removed from the sugar backbone by action of a specific DNA glycolase and then the abasic sugar is removed by apurinic/apyrimidic (AP) lyase and AP endonuclease, leaving a one-nucleotide gap that is then filled in and ligated. base excision repair base excision repair A mechanism that repairs damaged DNA during the cell cycle by removing small, non-helix-distorting nucleotide base lesions, which could otherwise cause mutations by mispairing or lead to breaks in DNA during replication. BER is initiated by DNA glycosylases that recognise and remove damaged or inappropriate bases, forming AP sites which are then cleaved by an AP endonuclease. The single-strand break formed by AP endonuclease are then processed by either short-patch (a single nucleotide is replaced), or long-patch (2–10 new nucleotides are synthesised) repair. AcronymsSeeBER
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