malakoplakia


mal·a·co·pla·ki·a

, malakoplakia (mal'ă-kō-plā'kē-ă, mal'a-kō-plā'kē-a), Rare lesion in the mucosa of the urinary bladder and other organs, more frequent in women, characterized by numerous mottled yellow and gray soft plaques and nodules that consist of numerous macrophages and calcospherites (Michaelis-Guttmann bodies) that may form around intracellular bacteria, usually Escherichia coli. [malaco- + G. plax, plate, plaque]

malakoplakia

A rare (less than 500 cases in the world literature) granulomatous lesion characterised by soft, yellow, elevated and friable 3–4 cm mucosal plaques of the genitourinary tract (bladder, renal pelvis, ureter, uterus, broad ligament, endometrium, testes, epididymis, prostate), with female:male ratio of 2.3:1 and, rarely, retroperitoneum, colon, stomach, appendix, lymph nodes, lungs, bone, skin. It is more common in immunosuppressed transplant recipients, a complication of recurrent infection, and attributed to defective phagocytosis. It may be associated with colorectal carcinoma.
Management
Long-term antibiotics, ascorbic acid, cholinergics; if recalcitrant, excision.

malakoplakia

malakos, Greek, soft plaque A lesion characterized by soft, yellow, elevated and friable 3-4 cm mucosal plaques of the GU tract–bladder, renal pelvis, ureter, uterus, broad ligament, endometrium, testes, epididymis, prostate and rarely, retroperitoneum, colon, stomach, appendix, lymph nodes, lungs, bone, skin; more common in immunosuppressed transplant recipients Treatment Long-term antibiotics, ascorbic acid, cholinergics; if recalcitrant, excision