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Malate Dehydrogenase
malate dehydrogenase[′ma‚lāt dē′hī·drə·jə‚nās] (biochemistry) malic enzyme Malate Dehydrogenase an enzyme of the oxidoreductase class widely distributed in animal and plant cells, where it catalyzes the dehydrogenation of malic acid to oxalacetic acid in the tricarboxylic acid cycle. In higher plants and animals there are two different malate dehydrogenases, one localized in the mitochondria and the other in the soluble fraction of the cell. Decarboxylating malate dehydrogenase (malic enzyme) catalyzes the readily reversible formation reaction of malic acid from pyruvic acid and CO2, as well as the decarboxylation of oxalacetic acid. malate dehydrogenase
ma·late de·hy·dro·gen·ase (MD), an enzyme that, using either NAD+ or NADP+, catalyzes the dehydrogenation of malate to oxaloacetate or its decarboxylation to pyruvate and CO2. At least six malate dehydrogenases are known, distinguished by their products, use of NAD+ or NADP+, and specificity of substrate (one acts on d-malate, the rest act on l-malate); one of these proteins is an enzyme in the tricarboxylic acid cycle. Synonym(s): malic acid dehydrogenase, malic dehydrogenase, malic enzyme, pyruvic-malic carboxylasemalate dehydrogenase An oxidoreductase (EC 1.1.1.37) in mitochondria and the cytosol that catalyses the reversible NAD+/NADH reaction in the presence of S-malate, yielding oxaloacetate, a step in the citric acid cycle. Malate dehydrogenase is increased in myocardial infarction, hepatocellular necrosis, megaloblastic anaemia, and cancer.mal·ate de·hy·dro·gen·ase (mal'āt dē-hī'drō-jĕ-nās) Any enzyme that catalyzes the dehydrogenation of malate to oxaloacetate. At least six are known; one is an enzyme in the tricarboxylic acid cycle. AcronymsSeeMDH |