| 释义 |
antinuclear antibody
antinuclear antibodyn. Abbr. ANA Any of various antibodies that react with nuclear antigens such as nucleic acids and histones and are often present in the blood of people with systemic autoimmune rheumatic diseases.antinuclear antibody
antinuclear antibody[¦an·tē¦nü·klē·ər ′an·tə‚bäd·ē] (immunology) Antibody to deoxyribonucleic acid, ribonucleic acid, histone, or nonhistone proteins found in the serum of individuals with certain autoimmune diseases. Abbreviated ANA. antinuclear antibody
an·ti·nu·cle·ar an·ti·bod·y (ANA), an antibody showing an affinity for nuclear antigens including DNA and found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and certain collagen diseases, and in some of their healthy relatives; as well as about 1% of otherwise healthy people. Different antinuclear antibodies generate distinctive patterns on immunofluorescence staining tests. These patterns have clinical relevance and reflect which nuclear constituents (autoantigens) are generative specific antibody responses.antinuclear antibodyn. Abbr. ANA Any of various antibodies that react with nuclear antigens such as nucleic acids and histones and are often present in the blood of people with systemic autoimmune rheumatic diseases.antinuclear antibody Any of a number of circulating antibodies directed against various antigens in the nucleus, including histone, double- and single-stranded DNA, and ribonucleoprotein. ANAs are often present in serum of patients with SLE and other connective tissue diseases.antinuclear antibody ANA Immunology Any of a number of circulating antibodies that are directed against various antigens in the nucleus, including histone, double- and single-stranded DNA, and ribonucleoprotein; ANAs are often present in serum of Pts with SLE and other connective tissue diseases. See Speckled pattern. an·ti·nu·cle·ar an·ti·bod·y , antinuclear factor (ANA, ANF) (an'tē-nū'klē-ăr an'ti-bod-ē, fak'tŏr) An antibody showing an affinity for cell nuclei, demonstrated by exposing a cell substrate to the serum to be tested, followed by exposure to an antihuman-globulin serum; found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and certain collagen diseases, in some of their healthy relatives, and in about 1% of unaffected people. an·ti·nu·cle·ar an·ti·bod·y , antinuclear factor(ANA, ANF) (an'tē-nū'klē-ăr an'ti-bod-ē, fak'tŏr) An antibody showing an affinity for cell nuclei, demonstrated by exposing a cell substrate to the serum to be tested, followed by exposure to an antihuman-globulin serum; found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and some collagen diseases. AcronymsSeeanaphylactoidThesaurusSeeAna |