malignant neuroleptic syndrome

A life-threatening condition that affects < 1% of patients exposed to neuroleptics (e.g., phenothiazine, butyrophenones).

Clinical findings
Fever, autonomic instability, muscle rigidity, tremor, cognitive changes, encephalopathy, delirium, and myoglobinuria, which start 1–3 days after beginning neuroleptic agents, including antipsychotics or antidepressants.
Lab
Increased CK, leukocytosis.
Management
Stop drugs, antipyretics, cooling blankets, dantrolene, bromocriptine.

malignant neuroleptic syndrome

A complex that affects < 1% of Pts exposed to neuroleptics–phenothiazine, butyrophenones Clinical Onset 1-3 days after beginning antidepressant therapy, which causes hyperthermia, autonomic instability, muscle rigidity, myoglobinuria

单词	malignant neuroleptic syndrome
释义	DictionarySeeneuroleptic malignant syndrome malignant neuroleptic syndrome malignant neuroleptic syndrome A life-threatening condition that affects < 1% of patients exposed to neuroleptics (e.g., phenothiazine, butyrophenones). Clinical findings Fever, autonomic instability, muscle rigidity, tremor, cognitive changes, encephalopathy, delirium, and myoglobinuria, which start 1–3 days after beginning neuroleptic agents, including antipsychotics or antidepressants. Lab Increased CK, leukocytosis. Management Stop drugs, antipyretics, cooling blankets, dantrolene, bromocriptine. malignant neuroleptic syndrome A complex that affects < 1% of Pts exposed to neuroleptics–phenothiazine, butyrophenones Clinical Onset 1-3 days after beginning antidepressant therapy, which causes hyperthermia, autonomic instability, muscle rigidity, myoglobinuria
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