antioxidant therapy

antioxidant therapy

A general term for the use of any agent (e.g., antioxidant vitamins, glutathione reductase, superoxide dismutase) to reduce or eliminate oxygen free-radicals (OFRs) or excited oxygen molecules, which are by-products of normal metabolic reactions; excess OFRs have been linked to cancer secondary to OFR-induced DNA damage, and to cardiovascular disease secondary to FR-induced oxidation of low-density lipoprotein (LDL)-cholesterol to a more atherogenic form. In cardiology, antioxidant therapy attempts to block the oxidative modification of LDL, which is thought to be an early step in fatty streak development, atherogenesis and atherosclerosis-related pathologies, including coronary artery disease and cerebrovascular accidents.

antioxidant therapy

Therapeutics A general term for the use of any agent–eg, antioxidant vitamins, glutathione reductase, superoxide dismutase, to 'scavenge' O2 free radicals–OFRs or excited O2 molecules, which are by-products of normal metabolic reactions; excess OFRs have been linked to cancer 2º to OFR-induced DNA damage, and to cardiovascular disease 2º to OFR-induced oxidation of LDL-cholesterol to a more atherogenic form; in cardiology, AT attempts to block the oxidative modification of LDL, which is thought to be an early step in fatty streak development, atherogenesis and ASHD-related pathologies–eg, CAD and CVAs. See Antioxidant, Antioxidant vitamin.