N5, N10-methylenetetrahydrofolate reductase

N5, N10-meth·yl·ene·tet·ra·hy·dro·fo·late re·duc·tase

(meth'il-ēn-tet'ră-hī'drō-fō'lāt rĕ-duk'tās), An enzyme that converts N5,N10-methylenetetrahydrofolate to N5,N10-methenyltetrahydrofolate using NADP+; a deficiency of this enzyme results in an accumulation of l-homocysteine and severe neurological disturbances.