| 释义 |
mechanism of action
mech´an`ism of ac´tion
| n. | 1. | (Medicine, Biochemistry) The mechanism{2} by which a pharmacologically active substance produces an effect on a living organism or in a biochemical system; as, the mechanism of action of actinomycin involves its binding to DNA. The mechanism of action is usually considered to include an identification of the specific molecular targets to which a pharmacologically active substance binds or whose biochemical action it influences; a general recognition of the broad biochemical pathways (such as DNA synthesis, protein synthesis, cholesterol synthesis) which are inhibited or affected by a substance is termed its mode of action. |
EncyclopediaSeemechanismmechanism of action
mechanism of action (1) The manner in which a therapeutic agent acts, which includes blocking of receptors, enzymes, stimulating hormone production, etc.
(2) The physiologic or biochemical processes within the body that are affected by a drug’s action, producing a given response.mechanism of actionThe means by which a drug exerts its effects on cells or tissues. It may have specific binding sites, receptor activation, enzymatic activity, or solubility. See also: mechanismAcronymsSeeMOA |