| 单词 | adenylate cyclase |
| 释义 | adenylate cyclasea·den·yl·ate cyclase(ə-dĕn′əl-ĭt, ăd′n-ĭl′ĭt) also a·den·yl cyclase (ə-dĕn′əl, ăd′n-ĭl)adenylate cyclaseadenylate cyclase[ah-den´ĭ-lāt si´clās]a·den·y·late cy·claseadenylate cyclase(ə-dĕn′əl-ĭt, ăd′n-ĭl′ĭt) alsoadenyl cyclase(ə-dĕn′əl, ăd′n-ĭl)Adenylate CyclaseAn enzyme that catalyses ATP to form 3’,5’-cyclic AMP and inorganic pyrophosphate. G proteins dissociate into GTP-bound alpha subunits—activating adenylyl cyclase, retinal phosphodiesterase, phospholipase C, and ion channels—and a complex of beta and gamma subunits, selectively activating certain forms of adenylate cyclase following interaction with the cell receptors. Adenylate cyclase is intimately linked to the receptor-G protein machinery on the cytoplasmic face of cell membrane, which generates the second messenger, cAMP, when stimulated by an extracellular message in the form of receptor binding of a hormone or other ligand, light, or odours. Adenylate cyclase is the prototypic second messenger generator, and is regulated by one or the other arm of the phospholipase C pathway. It is further regulated by cyclic changes in cAMP and internal Ca2+ levels.a·den·y·late cy·clase(ă-den'i-lāt sī'klās)Synonym(s): 3', 5'-cyclic AMP synthetase. adenylate cyclaseThe enzyme that converts ADENOSINE TRIPHOSPHATE (ATP) to cyclic AMP. |
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