| 释义 |
Meclomen
Thesaurus| Noun | 1. |  Meclomen - a nonsteroidal anti-inflammatory (trade name Meclomen) used to treat arthritismeclofenamate, meclofenamate sodiumnonsteroidal anti-inflammatory, nonsteroidal anti-inflammatory drug, NSAID - an anti-inflammatory drug that does not contain steroids; "NSAIDs inhibit the activity of both Cox-1 and Cox-2 enzymes"brand, brand name, marque, trade name - a name given to a product or service |
Meclomen
meclofenamate (me-kloe-fen-am-ate) meclofenamate, Meclomen (trade name) Classification Therapeutic: antirheumatics
Pharmacologic: fenamate
Pregnancy Category: UK
IndicationsManagement of mild to moderate pain, including: Management of excessive menstrual flow.ActionInhibits prostaglandin synthesis.Therapeutic effectsSuppression of pain and inflammation.PharmacokineticsAbsorption: Well absorbed from the GI tract.Distribution: Unknown.Protein Binding: >99%.Metabolism and Excretion: Metabolized by the liver; some active metabolites.Half-life: 40 min–2 hr.Time/action profile | ROUTE | ONSET | PEAK | DURATION | | PO (analgesic) | within 1 hr | unknown | 4–6 hr | | PO (anti-inflammatory) | days | 2–3 wk | days |
Contraindications/PrecautionsContraindicated in: Hypersensitivity; Cross-sensitivity may occur with other NSAIDs, including aspirin; Active GI bleeding or ulcer disease.Use Cautiously in: Severe cardiovascular, renal, or hepatic disease; History of ulcer disease; Obstetric / Lactation / Pediatric: Pregnancy, lactation, or children <14 yr (safety not established; avoid use during 2nd half of pregnancy).Adverse Reactions/Side EffectsCentral nervous system- dizziness (most frequent)
- headache (most frequent)
- drowsiness
Ear, Eye, Nose, Throat- tinnitus
- visual disturbances
CardiovascularGastrointestinal- GI bleeding (life-threatening)
- drug-induced hepatitis (life-threatening)
- diarrhea (most frequent)
- dyspepsia (most frequent)
- nausea (most frequent)
- vomiting (most frequent)
- anorexia
- constipation
- discomfort
- flatulence
- stomatitis
GenitourinaryDermatologicHematologicMiscellaneous- allergic reactions including anaphylaxis and Stevens-Johnson syndrome (life-threatening)
- drug-induced systemic lupus erythematosus–like syndrome
InteractionsDrug-Drug interactionConcurrent use with aspirin may ↓ meclofenamate blood levels and may ↓ effectiveness.May ↑ risk of bleeding with thrombolytic agents, cefoperazone, cefotetan, valproic acid, clopidogrel, ticlopidine, eptifibatide, andtirofiban.Additive adverse GI side effects with aspirin, alcohol, corticosteroids, potassium supplements, and other NSAIDs.Probenecid ↑ blood levels and may ↑ toxicity.Chronic use with acetaminophen or gold compounds may ↑ the risk of adverse renal reactions.May decrease the effectiveness of antihypertensives or diuretics.May ↑ risk of hypoglycemia from oral hypoglycemic agents or insulins.↑ risk of hematologic adverse reactions with antineoplastics or radiation therapy.May ↑ levels and toxicity from lithium or methotrexate.↑ risk of nephrotoxicity with cyclosporine.↑ bleeding risk with anise, arnica, chamomile, clove, feverfew, garlic, ginger, ginkgo, Panax ginseng, and others.Route/DosageOral (Adults) Anti-inflammatory—200–400 mg/day in 3–4 divided doses. Analgesic—50–100 mg q 4–6 hr (not to exceed 400 mg/day). Dysmenorrhea/excessive menstrual flow—100 mg 3 times daily for up to 6 days or until cessation of menses.Availability (generic available)Capsules: 50 mg, 100 mg Nursing implicationsNursing assessment- Patients who have asthma, aspirin-induced allergy, and nasal polyps are at increased risk for developing hypersensitivity reactions. Monitor for rhinitis, asthma, and urticaria.
- Assess patient for skin rash frequently during therapy. Discontinue meclofenamate at first sign of rash; may be life-threatening. Stevens-Johnson syndrome or toxic epidermal necrolysis may develop. Treat symptomatically; may recur once treatment is stopped.
- Arthritis: Assess pain and range of movement before and periodically during therapy.
- Pain: Assess location, duration, and intensity of pain before and 1 hr after administration.
- Lab Test Considerations: Evaluate BUN, serum creatinine, CBC, and liver function tests periodically in patients receiving prolonged therapy.
- May ↑serum potassium, BUN, serum creatinine, alkaline phosphatase, LDH, AST, and ALT levels. May ↓ hemoglobin and hematocrit concentrations, leukocyte and platelet counts, and CCr.
- Effects on bleeding time are minimal.
Potential Nursing DiagnosesAcute pain (Indications)
Impaired physical mobility (Indications)
Implementation- Administration in higher than recommended doses does not provide increased effectiveness but may cause increased side effects.
- Coadministration with opioid analgesics may have additive analgesic effects and may permit lower opioid doses.
- Oral: For rapid initial effect, administer 30 min before or 2 hr after meals. May be administered with food, milk, or antacids to decrease GI irritation.
- Dysmenorrhea: Administer as soon as possible after the onset of menses. Prophylactic treatment has not been shown to be effective.
Patient/Family Teaching- Advise patients to take this medication with a full glass of water and to remain in an upright position for 15–30 min after administration.
- Instruct patient to take medication exactly as directed. If a dose is missed, take as soon as remembered but not if almost time for next dose. Do not double doses.
- May occasionally cause drowsiness or dizziness. Advise patient to avoid driving or other activities requiring alertness until response to the medication is known.
- Caution patient to avoid the concurrent use of alcohol, aspirin, acetaminophen, or other OTC medications without consulting health care professional.
- Advise patient to inform health care professional of medication regimen before treatment or surgery.
- Caution patient to wear sunscreen and protective clothing to prevent photosensitivity reactions.
- Advise patient to consult health care professional if rash, itching, visual disturbances, tinnitus, weight gain, edema, black stools, persistent headache, or influenza-like syndrome (chills, fever, muscle aches, pain) occurs.
- Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Evaluation/Desired Outcomes- Decreased severity of pain.
- Improved joint mobility. Partial arthritic relief is usually seen within a few days, but maximum effectiveness may require 2–3 wk of continuous therapy. Patients who do not respond to one NSAID may respond to another.
- Decreased menstrual flow.
meclofenamate An anthranilic-type NSAID, which is tightly bound to albumin, used for arthritic complaints, dysmenorrhoea and vascular headache.
T1/2
3–4 hours.
Excretion
Renal, gastrointestinal.Meclomen
Related to Meclomen: ProtonixSynonyms for Meclomennoun a nonsteroidal anti-inflammatory (trade name Meclomen) used to treat arthritisSynonyms- meclofenamate
- meclofenamate sodium
Related Words- nonsteroidal anti-inflammatory
- nonsteroidal anti-inflammatory drug
- NSAID
- brand
- brand name
- marque
- trade name
|