MTHFD1

A gene on chromosome 14q24 that encodes an enzyme that has three distinct enzymatic activities:
• 5,10-methylenetetrahydrofolate dehydrogenase (E.C. 1.5.1.5);
• 5,10-methenyltetrahydrofolate cyclohydrolase (E.C. 3.5.4.9); and
• 10-formyltetrahydrofolate synthetase (E.C. 6.3.4.3).
These activities interconvert methyl (1-carbon) derivatives of tetrahydrofolate, which serve as substrates for methionine, thymidylate and de novo purine synthesis.
Molecular pathology
Defects in MTHFD1 may increase susceptibility to folate-sensitive neural tube defects and colorectal cancer.

单词	mthfd1
释义	MTHFD1 MTHFD1 A gene on chromosome 14q24 that encodes an enzyme that has three distinct enzymatic activities: • 5,10-methylenetetrahydrofolate dehydrogenase (E.C. 1.5.1.5); • 5,10-methenyltetrahydrofolate cyclohydrolase (E.C. 3.5.4.9); and • 10-formyltetrahydrofolate synthetase (E.C. 6.3.4.3). These activities interconvert methyl (1-carbon) derivatives of tetrahydrofolate, which serve as substrates for methionine, thymidylate and de novo purine synthesis. Molecular pathology Defects in MTHFD1 may increase susceptibility to folate-sensitive neural tube defects and colorectal cancer.
随便看	peroxisome proliferator-activated receptor interacting protein peroxisome proliferator-activated receptor-interacting protein peroxisome receptor 1 peroxisomes peroxisome targeting signal 2 receptor peroxisome targeting signal type 1 peroxisome targeting signal type-2 peroxo- peroxo acid peroxy peroxy- peroxyacetic acid peroxyacetyl nitrate peroxyacetylnitrate peroxy acid peroxybenzoyl nitrate peroxy-disulfuric acid peroxydol peroxyformic acid peroxyl peroxymonosulfuric acid peroxynitrate peroxynitrite peroxynitrous acid peroxysome