NK/T-cell lymphoma nasal type

A primary lymphoma of the nasal cavity which is linked to Epstein-Barr virus infection, HIV, inherited immunodeficiencies (e.g., ataxia-telangiectasia), common-variable immunodeficiency disease, Chédiak-Higashi syndrome, autoimmune disease (e.g., Sjögren syndrome), coeliac disease, and chemical exposures (e.g., dioxin, herbicides, phenytoin, prior radiation or chemotherapy). It is remarkable for having a much higher mortality and much lower response to chemo- and radiotherapy.
Clinical findings
Presents as a nasal mass that extends to the skin, as a mid-facial destructive lesion, or as multiple erythaematous nodules which later ulcerate.
Local symptoms
Facial pain and swelling, diplopia, proptosis, loss of visual acuity, orbital mass and swelling, nasal obstruction, septal perforation, purulent discharge, sinusitis, epistaxis, hearing loss, oral ulcers, odynophagia, dysphagia, velopharyngeal incompetence, trismus, halitosis, otalgia, neck mass.
Systemic symptoms
B symptoms (weight loss, fever, fatigue, night sweats, bone pain) occur in less than 20% of patients.
Prognosis
Clinically aggressive; dismal prognosis.

单词	nk/t-cell lymphoma nasal type
释义	NK/T-cell lymphoma nasal type NK/T-cell lymphoma nasal type A primary lymphoma of the nasal cavity which is linked to Epstein-Barr virus infection, HIV, inherited immunodeficiencies (e.g., ataxia-telangiectasia), common-variable immunodeficiency disease, Chédiak-Higashi syndrome, autoimmune disease (e.g., Sjögren syndrome), coeliac disease, and chemical exposures (e.g., dioxin, herbicides, phenytoin, prior radiation or chemotherapy). It is remarkable for having a much higher mortality and much lower response to chemo- and radiotherapy. Clinical findings Presents as a nasal mass that extends to the skin, as a mid-facial destructive lesion, or as multiple erythaematous nodules which later ulcerate. Local symptoms Facial pain and swelling, diplopia, proptosis, loss of visual acuity, orbital mass and swelling, nasal obstruction, septal perforation, purulent discharge, sinusitis, epistaxis, hearing loss, oral ulcers, odynophagia, dysphagia, velopharyngeal incompetence, trismus, halitosis, otalgia, neck mass. Systemic symptoms B symptoms (weight loss, fever, fatigue, night sweats, bone pain) occur in less than 20% of patients. Prognosis Clinically aggressive; dismal prognosis.
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