nuclear factor-kappaB

nuclear factor-κB

an evolutionarily conserved eukaryotic transcription factor system that contributes to the mounting of an effective immune response but also plays an important role in many other cellular processes. NF-κB and its regulators are linked to signal transduction pathways as well as transcriptional activation events that mediate critical stages of cell proliferation, development, and apoptosis.

nu·cle·ar fac·tor-κB

(nū'klē-ăr fak'tŏr) A transcription factor associated with cytokine production.