nuclear hormone receptor

member of large family of intracellular molecules that act as ligand-activated transcription factors; all steroid and thyroid hormones and retinoic acid exert their effects through nuclear receptors. Member molecules that have no known ligand have been called orphan nuclear receptor.

DAX1

A gene (DSS-AHC critical region on the X chromosome, gene 1—formally known, per HUGO nomenclature, as NR0B1) located on chromosome Xp21.3 that encodes a protein containing a DNA-binding domain, which acts as a dominant-negative regulator of transcription mediated by the retinoic acid receptor. DAX1 also acts as an anti-testis gene by antagonising SRY.
Molecular pathology
DAX1 mutations cause both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.

单词	nuclear hormone receptor
释义	nuclear hormone receptor nuclear hormone receptor [¦nü·klē·ər ′hȯr‚mōn ri‚sep·tər] (cell and molecular biology) Any of a superfamily of proteins that directly regulate transcription in response to hormones and other ligands. nuclear hormone receptor nuclear hormone receptor member of large family of intracellular molecules that act as ligand-activated transcription factors; all steroid and thyroid hormones and retinoic acid exert their effects through nuclear receptors. Member molecules that have no known ligand have been called orphan nuclear receptor. DAX1 A gene (DSS-AHC critical region on the X chromosome, gene 1—formally known, per HUGO nomenclature, as NR0B1) located on chromosome Xp21.3 that encodes a protein containing a DNA-binding domain, which acts as a dominant-negative regulator of transcription mediated by the retinoic acid receptor. DAX1 also acts as an anti-testis gene by antagonising SRY. Molecular pathology DAX1 mutations cause both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
随便看	kimaf kimagure orange road kima international school of theology kimaki kimantaite, kazimira kimantaite, kazimira martynovna kimas kimax kimb kimball county kimball county, ne kimball county, nebraska kimball electronic laboratory, inc. kimball electronics group kimball, fiske kimball high school kimball hill homes kimball-manchester ambulatory care center kimball, sumner increase kimballton underground research facility kimball union academy kimball, william wirt kimbalom kimbanguism kimbanguist church