Klippel-Feil syndrome

[klĭ-pel´ fīl] shortness of the neck due to reduction in the number of cervical vertebrae or the fusion of multiple hemivertebrae into one osseous mass, with limitation of neck motion and low hairline.

Klip·pel-Feil syn·drome

(klip'ĕl fīl), [MIM*148900] a congenital defect manifested as a short neck, fusion of cervical vertebrae, and abnormalities of the brainstem and cerebellum; autosomal dominant inheritance, with most cases sporadic. Synonym(s): cervical fusion syndrome

Klippel-Feil syndrome

A condition (OMIM:214300) characterised by short neck, low hairline and decreased cervical motion.

Associated conditions
Congenital scoliosis (60%, most need treatment); Sprengel's deformity (failure of scapula to descend, remains attached to cervical spine by omovertebral bone or fibrous band) (33%); renal disease, often with aplasia (33%); synkinesis (mirror movements); congenital heart disease; brain stem defects; congenital cervical stenosis; syndactyly and hypoplastic thumb; hearing loss (30%).
Pathogenesis
Klippel-Feil syndrome is characterised by congenital failure of normal segmentation of cervical somites at 3–8 weeks's gestation, resulting in two or more fused cervical segments.

Klippel-Feil sequence/syndrome

The combination of short neck, low hairline at nape of the neck and limited movement of head, due to a defect in the early development of the spinal column in the neck–the cervival vertebrae

Klip·pel-Feil syn·drome

(klipĕl fīl sindrōm) A congenital abnormality of the spine characterized by a reduction in the number of cervical vertebrae and their fusion. See this page.

Feil,

André, French physician, 1884–. Feil-Klippel syndrome - Synonym(s): Klippel-Feil syndromeKlippel-Feil syndrome - see under Klippel

Klippel,

Maurice, French neurologist, 1858-1942. Feil-Klippel syndrome - Synonym(s): Klippel-Feil syndromeKlippel-Feil syndrome - a congenital defect manifested as a short neck, extensive fusion of the cervical vertebrae, and abnormalities of the brainstem and cerebellum. Synonym(s): cervical fusion syndrome; Feil-Klippel syndromeKlippel-Trenaunay-Weber syndrome - an anomaly of the extremity in which there is a combination of angiomatosis and anomalous development of the underlying bone and muscle, sometimes associated with localized gigantism. Synonym(s): angioosteohypertrophy syndrome; congenital dysplastic angiectasia; hemangiectatic hypertrophy

Klip·pel-Feil syn·drome

(klipĕl fīl sindrōm) [MIM*148900] A congenital abnormality of the spine characterized by a reduction in the number of cervical vertebrae and their fusion.

单词	klippel-feil syndrome
释义	DictionarySeesyndrome Klippel-Feil syndrome Klippel-Feil syndrome [klĭ-pel´ fīl] shortness of the neck due to reduction in the number of cervical vertebrae or the fusion of multiple hemivertebrae into one osseous mass, with limitation of neck motion and low hairline. Klip·pel-Feil syn·drome (klip'ĕl fīl), [MIM148900] a congenital defect manifested as a short neck, fusion of cervical vertebrae, and abnormalities of the brainstem and cerebellum; autosomal dominant inheritance, with most cases sporadic. Synonym(s): cervical fusion syndrome Klippel-Feil syndrome A condition (OMIM:214300) characterised by short neck, low hairline and decreased cervical motion. Associated conditions Congenital scoliosis (60%, most need treatment); Sprengel's deformity (failure of scapula to descend, remains attached to cervical spine by omovertebral bone or fibrous band) (33%); renal disease, often with aplasia (33%); synkinesis (mirror movements); congenital heart disease; brain stem defects; congenital cervical stenosis; syndactyly and hypoplastic thumb; hearing loss (30%). Pathogenesis Klippel-Feil syndrome is characterised by congenital failure of normal segmentation of cervical somites at 3–8 weeks's gestation, resulting in two or more fused cervical segments. Klippel-Feil sequence/syndrome The combination of short neck, low hairline at nape of the neck and limited movement of head, due to a defect in the early development of the spinal column in the neck–the cervival vertebrae Klip·pel-Feil syn·drome (klipĕl fīl sindrōm) A congenital abnormality of the spine characterized by a reduction in the number of cervical vertebrae and their fusion. See this page. Feil, André, French physician, 1884–. Feil-Klippel syndrome* - Synonym(s): Klippel-Feil syndromeKlippel-Feil syndrome - see under Klippel Klippel, Maurice, French neurologist, 1858-1942. Feil-Klippel syndrome - Synonym(s): Klippel-Feil syndromeKlippel-Feil syndrome - a congenital defect manifested as a short neck, extensive fusion of the cervical vertebrae, and abnormalities of the brainstem and cerebellum. Synonym(s): cervical fusion syndrome; Feil-Klippel syndromeKlippel-Trenaunay-Weber syndrome - an anomaly of the extremity in which there is a combination of angiomatosis and anomalous development of the underlying bone and muscle, sometimes associated with localized gigantism. Synonym(s): angioosteohypertrophy syndrome; congenital dysplastic angiectasia; hemangiectatic hypertrophy Klip·pel-Feil syn·drome (klipĕl fīl sindrōm) [MIM*148900] A congenital abnormality of the spine characterized by a reduction in the number of cervical vertebrae and their fusion. AcronymsSeedumbfounded
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