lose one's buttons

lose (one's) buttons

To be or become mentally deficient, incompetent, or deranged; to become of unsound mind. My poor grandmother started losing her buttons after she had a stroke on her 84th birthday. I've been so sleep deprived lately that it feels like I'm losing my buttons!See also: button, lose

lose one's buttons

see under have all one's buttons. See also: button, lose