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Lou Gehrig disease
TranslationsEncyclopediaSeeamyotrophic lateral sclerosisLou Gehrig disease
a·my·o·tro·phic lat·er·al scle·ro·sis (ALS), a fatal degenerative disease involving the corticobulbar, corticospinal, and spinal motor neurons, manifested by progressive weakness and wasting of muscles innervated by the affected neurons; fasciculations and cramps commonly occur. The disorder is 90-95% sporadic in nature (although a number of cases are inherited as an autosomal dominant trait [MIM*105400]), affects adults (typically, older adults), and usually is fatal within 2-5 years of onset. It is in the most common subgroup of motor neuron diseases, and the only one manifested by a combination of upper and lower abnormalities. Variants include: progressive bulbar palsy, in which isolated or predominant lower brainstem motor involvement occurs; primary lateral sclerosis, in which only upper motor neuron abnormalities are seen; and progressive spinal muscle atrophy, in which only lower motor neuron dysfunction is noted. See also entries under Henry Louis Gehrig Synonym(s): Aran-Duchenne disease, Charcot disease, Duchenne-Aran disease, Lou Gehrig disease, motor neuron disease (1) , progressive muscular atrophy, progressive spinal amyotrophyThe popular name in the US for amyotrophic lateral sclerosis, in honor of Lou Gehrig, the ‘Iron Horse’, a first baseman for the NY Yankees (1925-39)Lou Gehrig disease Amyotrophic lateral sclerosis, see there. amy·o·tro·phic lat·er·al scle·ro·sis (ALS) (ā-mīō-trōfik latĕr-ăl skler-ōsis) A disease of the motor tracts of the lateral columns and anterior horns of the spinal cord, causing progressive muscular atrophy, hyperactive deep tendon reflexes, fibrillary twitching, and spastic irritability of muscles; associated with a defect in superoxide dismutase.
Synonym(s): Aran-Duchenne disease, Charcot disease, Cruveilhier disease, Duchenne-Aran disease, Lou Gehrig disease, progressive muscular atrophy. Gehrig, Henry Louis, U.S. baseball player for the New York Yankees, 1903-1941, victim of Lou Gehrig disease. Lou Gehrig disease - a disease of the motor tracts of the lateral columns and anterior horns of the spinal cord, causing progressive muscular atrophy. Synonym(s): amyotrophic lateral sclerosis; Aran-Duchenne disease; Aran-Duchenne dystrophy; Charcot disease; Cruveilhier disease; Cruveilhier palsy; Duchenne-Aran diseasePatient discussion about Lou Gehrig diseaseQ. What are the presenting signs of ALS? Are the upper or lower extremeties affected initialilly? A. The most common presenting sign of ALS is asymmetric limb weakness, usually starting with the hands (problems with pinching, writing, holding things etc.) shoulders (lifting arms above head etc.) or legs (problems walking).
Other presenting signs may be problems with speaking or swallowing, although these are less common.
You may read more here:
www.nlm.nih.gov/medlineplus/amyotrophiclateralsclerosis.html
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