| Acronym | Definition |
|---|
| OSRS➣Old School RuneScape (gaming) |
| OSRS➣Ohio State Radiological Society (est. 1940) |
| OSRS➣Ocean Sciences Research Section (US NSF) |
| OSRS➣Operation Safety Requirements Specification |
| OSRS➣Oil Spill Response Systems |
| OSRS➣Orbital Structural Reference System |
| OSRS➣Old Scratch Revival Singers (band) |