NALP3 inflammasome

NALP3 inflammasome

A well-characterised inflammasome (a multiprotein cytoplasmic complex which activates one or more caspases, leading to the processing and secretion of pro-inflammatory cytokines—e.g., IL-1 beta, IL-18 and IL-33) composed of NALP3, ASC, pro-caspase-1, and Cardinal. Assembly of inflammasomes depends on the NOD-like receptor family members, such as the NALP proteins.