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medulloblastomaenUK
medulloblastoma (mɪˌdʌləʊblæsˈtəʊmə) n (Pathology) a rapidly growing brain tumour that develops in children and is responsive to radiotherapymedulloblastomaa malignant tumor that commonly originates in the cere-bellum.See also: CancerTranslationsmedulloblastomaenUK
medulloblastoma[mə‚dəl·ə·bla′stō·mə] (medicine) A malignant neoplasm of the brain with a tendency to metastasize in the meninges. medulloblastomaenUK
medulloblastoma [mĕ-dul″o-blas-to´mah] a brain tumor composed of medulloblasts.me·dul·lo·blas·to·ma (med'yŭ-lō-blas-tō'mă), [MIM*155255] `A tumor consisting of neoplastic cells that resemble the undifferentiated cells of the primitive medullary tube; medulloblastomas are usually located in the vermis of the cerebellum, and may be implanted discretely or coalescently on the surfaces of the cerebellum, brainstem, and spinal cord; they comprise approximately 3% of all intracranial neoplasms, and occur most frequently in children; the neoplastic cells are compactly arranged, rounded or ovoid, with hyperchromatic nuclei and relatively scant cytoplasm, and lie in small and poorly defined groups, or, occasionally, in a pseudorosette pattern (Homer-Wright rosette). A type of primitive neuroectodermal tumor.medulloblastoma Primitive neuroectodermal tumor Neurology A malignant brain tumor that comprises ±1⁄4 of intracranial tumors in children and adolescents; it is most common at the midline of the cerebellum, and on the roof of 4th ventricle Clinical Presents with N&V, headache, ataxia, papilledema, nystagmus, irritability, lethargy, cranial nerve palsy, dizziness, altered vision Prognosis 2 yr-survival after relapse is 46% in those treated with salvage chemotherapy or RT, 0% in untreated Pts. See Brain tumor. Cf Glioblastoma. me·dul·lo·blas·to·ma (mĕ-dŭl'ō-blas-tō'mă) A tumor consisting of neoplastic cells that resemble the undifferentiated cells of the primitive medullary tube; medulloblastomas are usually located in the vermis of the cerebellum, comprise approximately 3% of all intracranial neoplasms, and occur most frequently in children. medulloblastoma A malignant brain tumour, most commonly affecting children and usually occurring in the CEREBELLUM or in the nearby roof of the FOURTH VENTRICLE. |