Meesmann corneal dystrophy

An autosomal dominant condition OMIM:122100 characterised by fragility of the anterior corneal epithelium due to the presence of innumerable microcysts. Patients are typically asymptomatic until adulthood when the corneal microcysts rupture, causing erosions and symptoms including photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment.
Pathology
Disorganised and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts.
Molecular pathology
Caused by defects of KRT3, which encodes cornea-specific keratin 3, and KRT12, which encodes cornea-specific keratin 12 (which together form a heterotetrameric complex).

单词	meesmann corneal dystrophy
释义	Meesmann corneal dystrophy Meesmann corneal dystrophy An autosomal dominant condition OMIM:122100 characterised by fragility of the anterior corneal epithelium due to the presence of innumerable microcysts. Patients are typically asymptomatic until adulthood when the corneal microcysts rupture, causing erosions and symptoms including photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Pathology Disorganised and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. Molecular pathology Caused by defects of KRT3, which encodes cornea-specific keratin 3, and KRT12, which encodes cornea-specific keratin 12 (which together form a heterotetrameric complex).
随便看	conrad von hötzendorf, franz conrad von hötzendorf, franz, graf conrad waddington conrad witz conrail conrail historical society conrail quality conrail shared assets conraua goliath conrb conreal conrector conred conref conrep conrey con rod conrod con rods conrod technical services con: roe conroe conroe area christian home educators conroe area youth baseball conroe independent school district